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Insulin sensitive-intensifying agent from plant and its preparing method and use

An insulin sensitizer and plant technology, applied in the field of insulin sensitizer and its preparation, can solve the problems of acute edema induced by heart failure patients, serious side effects, and small quantity and variety, so as to enhance insulin sensitivity and reduce fasting blood sugar , the effect of increasing the insulin sensitivity index

Inactive Publication Date: 2005-12-21
TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as time goes by, cases of liver toxicity appear from time to time. The adverse reactions include palpitations, headache, itching, diarrhea, edema, dyspnea, weight gain, etc., and even patients with potential heart failure due to fluid retention induced acute edema
At present, most of the drugs that have the effect of enhancing insulin sensitivity on the market are still glitazones, which not only have fewer varieties and are expensive, but also have increasingly serious toxic and side effects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A preparation method of an insulin sensitizer derived from plants, comprising the following steps:

[0027] 1) Take 1Kg of pre-dried whole herb of purslane (Partulace oleracea L), crush it into purslane coarse powder with a size of about 3mm, add sodium hydroxide and ethanol, and make the concentration of 3% (g / ml) respectively and 3L of 60% (ml / ml) alkaline alcohol solution, heated to make it boil slightly, extracted for 2 hours, and collected the extract; added 3L of the above-mentioned alkaline alcohol solution to the remaining medicinal residues, repeated the above operation twice, and heated successively Extract for 1h and 0.5h, then combine the extracts from the 3 operations, about 7L, recover the ethanol in it until it has no alcohol smell, and obtain a concentrated solution of about 3000ml.

[0028] 2) Put this concentrated solution on a 1m×10cm polyamide column, elute with 95% (ml / ml) ethanol, stop when the eluate is greenish brown, collect 2L of eluent, and re...

Embodiment 2

[0031] A preparation method of an insulin sensitizer derived from plants, comprising the following steps:

[0032] 1) Take 1Kg of pre-dried whole herb of purslane (Partulace oleracea L), grind it into purslane coarse powder with a size of about 2mm, add sodium hydroxide and ethanol, and make the concentration of 2.8% (g / ml) respectively and 4L of 65% (ml / ml) alkaline alcohol solution, heated to make it boil slightly, extracted for 2 hours, and collected the extract; added 3L of the above-mentioned alkaline alcohol solution to the remaining medicinal residue, repeated the above operation three times, and heated and extracted in turn 1h, 0.5h, 0.5h, and then combine the extracts from the 4 operations, about 12L, recover the ethanol in it until there is no alcohol smell, and obtain a concentrated solution of about 3500ml.

[0033] 2) 1m × 10cm polyamide column on this concentrate, elute with 93% (ml / ml) ethanol, stop when the eluate is greenish brown, collect and obtain eluate 2....

Embodiment 3

[0036] A preparation method of an insulin sensitizer derived from plants, comprising the following steps:

[0037] 1) Take 1Kg of pre-dried whole herb of purslane (Partulace oleracea L), crush it into purslane coarse powder with a size of about 5mm, add sodium hydroxide and ethanol, and make the concentration of 3.2% (g / ml) respectively and 2L of 58% (ml / ml) alkaline alcohol solution, heated to slightly boil, extracted for 2 hours, and collected the extract; then added 2L of the above-mentioned alkaline alcohol solution to the remaining medicinal residues, repeated the above operation twice, and heated successively Extract for 1h and 0.5h, then combine the extracts from the three operations, about 5L, recover the ethanol in it until it has no alcohol smell, and obtain a concentrated solution of about 2500ml.

[0038] 2) Put this concentrate on a 1m×10cm polyamide column, elute with 97% (ml / ml) ethanol, stop when the eluate is greenish brown, collect 1.5L of eluate, and recover...

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Abstract

The present invention relates to an insulin sensitivity-enhancing agent obtained from plant, its preparation method and application. Said insulin sensitivity-enhancing agent is active component extract of Chinese medicinal and edible dual-purpose plant portulaca, in the active component extract of portulaca the content of portulaca total flavone is 20-60% of its total weight. Said active component extract of Chinese medicinal material portulaca can be used for making functional food with the functions of reducing sugar and regulating blood-lipid. Besides, said invention also provides its two preparation processes and their concrete steps.

Description

technical field [0001] The invention relates to a plant extract for preventing and treating diabetes and hyperlipidemia, in particular to a plant-derived insulin sensitizer and its preparation method and application. Background technique [0002] The core problem of type 2 diabetes is insulin resistance. Patients are often accompanied by relatively insufficient insulin secretion and reduced sensitivity of adipose tissue to insulin, resulting in disorders of glucose and lipid metabolism and increased free fatty acids in plasma. Effectively reducing the concentration of free fatty acids in serum can increase insulin-mediated glucose uptake in peripheral tissues, which can not only improve blood lipid metabolism disorders, but also help correct abnormal glucose metabolism. [0003] As a new class of hypoglycemic drugs, insulin sensitizers are known as an epoch-making achievement in the history of anti-diabetes. This class of drugs can improve insulin resis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
Inventor 陆付耳徐丽君
Owner TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH
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