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Applications of Tianshen capsules in preparation of drug used for treating type 2 diabetes lipid metabolic disorders and atherosclerosis

A technology for type 2 diabetes and glucose and lipid metabolism, which is applied in the field of medicine to achieve the effects of reducing fasting blood sugar, improving pancreatic cell lesions, and improving glucose and lipid metabolism disorders

Active Publication Date: 2015-04-15
三普药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether Tianshen Capsule has the effect of treating type 2 diabetic glucose and lipid metabolism disorder and preventing and treating atherosclerosis has not been reported.

Method used

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  • Applications of Tianshen capsules in preparation of drug used for treating type 2 diabetes lipid metabolic disorders and atherosclerosis
  • Applications of Tianshen capsules in preparation of drug used for treating type 2 diabetes lipid metabolic disorders and atherosclerosis
  • Applications of Tianshen capsules in preparation of drug used for treating type 2 diabetes lipid metabolic disorders and atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Effects of Tianshen Capsules on Glucolipid Metabolism Disorder in Type 2 Diabetes Model Rats

[0014] 1 Materials and methods

[0015] 1.1 Drugs and reagents

[0016] Tianshen Capsules, the content is tan powder, 0.4g / capsule, batch number: 120225, Sanpu Pharmaceutical Co., Ltd. Rosiglitazone sodium tablets, 4mg / tablet, batch number: 11100009, Taiji Group Chongqing Fuling Pharmaceutical Factory Co., Ltd. Streptozotocin (STZ), batch number: S-0130, Sigma, USA. Glucose determination kit, batch number 20120101, Shanghai Rongsheng Biopharmaceutical Co., Ltd. Triglyceride kit, batch number: 20120524, Beijing Beihua Kangtai Clinical Reagent Co., Ltd. Total cholesterol kit, batch number: 20120525, Beijing Beihua Kangtai Clinical Reagent Co., Ltd. High-density lipoprotein cholesterol kit, batch number: 20120411, Beijing Beihua Kangtai Clinical Reagent Co., Ltd. Low-density lipoprotein cholesterol kit, batch number: 20120229, Beijing Beihua Kangtai Clinical Reagent Co., Lt...

Embodiment 2

[0065] Tianshen capsule is composed of 13% rhodiola rosea, 21% salvia miltiorrhiza, 20% panax notoginseng, 15% chuanmuxiang, 13% medlar, 10% barberry bark, 6% seabuckthorn fresh The slurry is mixed with 2% starch.

Embodiment 3

[0067] Tianshen capsule is composed of 18% rhodiola rosea, 16% salvia miltiorrhiza, 10% panax notoginseng, 18% chuanmuxiang, 20% medlar, 15% barberry bark, 2% seabuckthorn fresh The pulp is mixed with 1% starch.

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PUM

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Abstract

The invention discloses applications of Tianshen capsules in preparation of a drug used for treating type 2 diabetes lipid metabolic disorders and atherosclerosis. The Tianshen capsules are capable of reducing serum total cholesterol (TC) and triglyceride (TG) levels of rats (P<0.05); reducing free fatty acid (FFA) levels significantly (P<0.01); increasing high-density lipoprotein (HDLC), fasting insulin (FBIns) levels and insulin sensitivity index significantly (P<0.01), improving pancreas cytopathic effects, and reducing fasting blood-glucose content to a certain degree. It is discovered that: the effects of Tianshen capsules in improving glycometabolism and lipid metabolic disorders of experimental type 2 diabetic rats relate to the effects of Tianshen casules in improving insulin sensitivity of tissue.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of Tianshen capsule in treating type 2 diabetes mellitus and lipid metabolism disorder and preventing and treating atherosclerosis. Background technique [0002] Type 2 diabetes is a metabolic disease. The main features of patients are insulin resistance, relative insulin deficiency and hyperglycemia. Drugs and insulin therapy are often required (especially as the disease progresses). Type 2 diabetes is non-ketotic hyperglycemia, and its complex and multifactorial metabolic changes often lead to damage and dysfunction of many organs. The most important part of type 2 diabetes is the cardiovascular system, morbidity and mortality a significant increase. Type 2 diabetes is often associated with obesity, high blood pressure, high cholesterol (mixed hyperlipidemia), and the so-called "metabolic syndrome" (also known as syndrome X, Reavan's syndrome, CHAOS syndro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/815A61P3/10A61P9/10
Inventor 张国清邹存生马世平傅强马占强
Owner 三普药业有限公司
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