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Antibacterial compound drug of sulbenicillin sodium for injection

A technology for sulfobenicillin sodium and injection, which is applied in the field of antibacterial combination drugs, can solve the problems of weak bacteriostatic effect, strong antibiotic resistance, poor antibacterial effect of sulfobenicillin sodium, etc., and achieves inhibitory activity, low toxicity, enhanced Antibacterial activity and antibacterial broad-spectrum effect

Inactive Publication Date: 2006-02-15
张舰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Sulbenicillin sodium is a broad-spectrum semi-synthetic penicillin antibiotic, mainly applicable to pneumonia, urinary tract infection, complicated skin and soft tissue infection and sepsis caused by Pseudomonas aeruginosa, some Proteus and other sensitive negative bacteria, etc. The effect of Proteus and the stability of penicillinase are better than carbenicillin. It is mainly used for the treatment of Pseudomonas aeruginosa infection clinically. Due to the long-term and extensive use or abuse of antibiotics in clinical practice, bacteria are resistant to antibiotics. Sex is getting stronger and stronger, and the antibacterial effect of single use of sulbenicillin sodium is also getting worse
[0003] Sulbactam sodium is a β-lactam inverse inhibitor. It has inhibitory effect on β-lactams, but its antibacterial effect is weak, so it cannot be used alone as an antibacterial drug. It is mainly used in combination with β-lactam antitoxins for various Severe infections and infections with drug-resistant strains

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1, get 500g sulbenicillin sodium and 500g sulbactam sodium and mix, below relative 45%, sub-package in 100 grade clean areas that meet GMP requirements.

Embodiment 2

[0012] Embodiment two, get 1000g sulbenicillin sodium and 500g sulbactam sodium mix evenly, below relative 45%, sub-package in 100 class clean areas that meet GMP requirements.

Embodiment 3

[0013] Embodiment three, get 3000g sulbenicillin sodium and 500g sulbactam sodium and mix, below relative 45%, in the 100 grade clean areas that meet GMP requirements.

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PUM

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Abstract

The invention provides an antibacterial composition of sulbenicillin sodium for injection, which comprises sulbenicillin sodium and sulbactam sodium by the weight ratio of 1-32:1. The antibacterial compound preparation has substantial synergy actions, and can effectively inhibit the reactivity of beta-lactamase.

Description

technical field [0001] The invention relates to an antibacterial combination drug of sulfbenicillin sodium for injection. Background technique [0002] Sulbenicillin sodium is a broad-spectrum semi-synthetic penicillin antibiotic, mainly applicable to pneumonia, urinary tract infection, complicated skin and soft tissue infection and sepsis caused by Pseudomonas aeruginosa, some Proteus and other sensitive negative bacteria, etc. The effect of Proteus and the stability of penicillinase are better than carbenicillin. It is mainly used for the treatment of Pseudomonas aeruginosa infection clinically. Due to the long-term and extensive use or abuse of antibiotics in clinical practice, bacteria are resistant to antibiotics. Sex is getting stronger and stronger, and the antibacterial effect of single use sulbenicillin sodium is also getting worse. [0003] Sulbactam sodium is a β-lactam inverse inhibitor. It has inhibitory effect on β-lactams, but its antib...

Claims

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Application Information

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IPC IPC(8): A61K31/431A61P31/04A61K31/43
Inventor 张舰李少华
Owner 张舰
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