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Chemical therapy medicine for treating rectum cancer

A chemotherapeutic drug and rectal cancer technology, applied in the field of chemotherapeutic drugs for the treatment of rectal cancer, can solve the problems of large side effects, unsatisfactory curative effect, large toxic and side effects of rectal cancer chemotherapy, etc., achieve bloody stool stop, ideal chemotherapy curative effect, no toxic side effects Effect

Inactive Publication Date: 2006-10-25
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the widely used oral method, especially the more routinely used intravenous chemotherapy drug method is the root cause of the extremely toxic side effects and unsatisfactory curative effect of rectal cancer chemotherapy.
Regardless of intravenous or oral administration, due to the special anatomical location of rectal cancer, the amount of drug reaching the local lesion is very small, resulting in affected curative effect and relatively large side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1 (5-fluorouracil content: 250mg / branch)

[0012] Present embodiment is the emulsion that is made from the raw material of following weight ratio:

[0013] 5-Fluorouracil 31250mg Liquid Paraffin 1250ml Vaseline 500ml

[0014] Lanolin 500ml Span 150ml Tween 350ml

[0015] Chinese medicine liquid 500ml.

[0016] The above-mentioned Chinese medicine liquid is made by adding 250 grams of Coptidis Rhizome and 250 grams of Agrimony to 2500 ml of water, decocting with slow fire to 1000 ml and collecting the liquid.

[0017] The preparation process of this embodiment is: add the above-mentioned Chinese medicine liquid and 5-fluorouracil into the emulsifier according to the above formula, add an appropriate amount of distilled water to a total of 5000ml, stir at 100RPM, add Span in turn at 50 degrees Celsius, soil temperature, and stir at 200RPM After 1 hour, add liquid paraffin, vaseline and lanolin in sequence, emulsify at 1000RPM for 10 minutes, and emulsify at...

Embodiment 2

[0018] Embodiment 2 (5-fluorouracil content: 400mg / branch)

[0019] Present embodiment is the emulsion that is made from the raw material of following weight ratio:

[0020] 5-Fluorouracil 50000mg Liquid Paraffin 1250ml Vaseline 500ml

[0021] Lanolin 500ml Span 150ml Tween 350ml

[0022] Chinese medicine liquid 500ml.

[0023] The above-mentioned Chinese medicine liquid is made by adding 250 grams of Coptidis Rhizome and 250 grams of Agrimony to 2500 ml of water, decocting with slow fire to 1000 ml and collecting the liquid.

[0024] The preparation process of this embodiment is the same as that of Example 1.

Embodiment 3

[0025] Embodiment 3 (5-fluorouracil content: 250mg / support)

[0026] Present embodiment is the emulsion that is made from the raw material of following weight ratio:

[0027] 5-Fluorouracil 31250mg Liquid Paraffin 1250ml Vaseline 500ml

[0028] Lanolin 500ml Span 150ml Tween 350ml

[0029] Chinese medicine liquid 500ml.

[0030] The above-mentioned Chinese medicine liquid is made by adding 150 grams of Coptidis Rhizome, 150 grams of Agrimony, 50 grams of Panax notoginseng, 50 grams of frankincense, 50 grams of myrrh, adding 2500 ml of water, decocting until 1000 ml and collecting the liquid.

[0031] The preparation process of this embodiment is the same as that of Example 1.

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PUM

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Abstract

The present invention relates to a chemotherapeutic medicine for curing rectal cancer. Said medicine is an emulsion made up by using 31250-50000 mg of 5-fluorouracil, 1250 ml of liquid paraffin wax, 500 ml of Vaseline, 500 ml of lanolin, 150 ml of Span. 350 ml of Tween ad 500 ml of liquid Chinese medicine throug a certain preparation process.

Description

technical field [0001] The invention relates to an anticancer chemotherapeutic drug, in particular to a chemotherapeutic drug for treating rectal cancer. Background technique [0002] Rectal cancer is a common malignant tumor of the digestive tract with a high incidence and a high mortality rate. The incidence of rectal cancer in my country is much higher than that in foreign countries, accounting for 60-75% of colorectal cancer, and it is more common in young and middle-aged people. In my country, rectal cancer is more common in the lower rectal cancer below the peritoneal reflexion, so the advantages of transanal clinical operation are obvious. Rectal cancer is often not detected early, so patients often lose the best time for surgery, or because it is easy to penetrate into the pelvic tissue in the early stage, the operation is difficult, and because of its low position, it is often due to consideration of the function of the anal sphincter, so the operation cannot be th...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61K31/513A61P35/00
Inventor 侯颖春
Owner SHAANXI NORMAL UNIV
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