Emodin emulsion for injection and its preparing process

A technology of emodin and emulsion, which is applied in the direction of anti-inflammatory agents, pharmaceutical formulas, emulsion delivery, etc., can solve the problems of unguaranteed clinical efficacy, high irritation, complex components, etc., achieve medical effects and improve the level of medicine, and reduce toxicity Side effects, effects of inhibiting pancreatic enzyme activity

Inactive Publication Date: 2006-11-08
欧苏 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are research reports on rhubarb injection with emodin as the active ingredient, mainly using rhubarb decoction pieces as raw material, after acid-base treatment and alcohol extraction, it is an injection made of mixed components of traditional Chinese medicine. This kind of rhubarb is used as the original medicinal material The content of anthraquinone derivatives varies greatly, it is difficult to control, and the composition is complex, which brings serious hidden dangers to the safety of medication, and is difficult to produce and market
Emodin is a strong hydrophobic substance, and the content of emodin in the rhubarb injection prepared above is extremely low, so the clinical efficacy cannot be guaranteed
[0004] Because emodin is a strong hydrophobic substance, it is insoluble in water, which brings great difficulties to its development
There is a patent application number: 200410002312.2, which reports the preparation of emodin injection, which is mainly prepared by inclusion of hydroxypropyl β-cyclodextrin. The toxic and side effects of hydroxypropyl β-cyclodextrin are not clear. There are special restrictions and requirements for safety. At the same time, the preparation method reported requires a large amount of ethanol, which is more irritating to the human body. At present, there is no ethanol standard for injection. freeze-dried powder
[0005] The content of emodin in rhubarb injection is low, and emodin injection is difficult, which brings safety hazards to clinical medication

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Dissolve 22.5g of glycerin, 12.0g of refined soybean lecithin in water for injection, and 10.0g of emodin in refined soybean oil, respectively heat to about 55°C, mix well, first emulsify fractionally in a tissue masher, and then The high-speed homogenizer emulsifies to meet the particle size of the preparation. Add water for injection to 1000ml, cool, fill, and sterilize to obtain emodin injection emulsion. This process is a 1000ml prescription, and the production can be expanded, and nitrogen protection is required during the production process.

Embodiment 2

[0037] Dissolve 25.0g of sorbitol in water for injection, dissolve 10g of refined lecithin and 20.0g of emodin in refined corn oil, heat to 70°C respectively, mix well, first fractionally emulsify in a tissue masher, and then pass through high-speed emulsification Homogenize and emulsify to meet the particle size of the preparation. Add water for injection to 1000ml, cool, and fill to obtain emodin injection emulsion.

Embodiment 3

[0039] Dissolve 55.5g of xylitol in water for injection, dissolve 12.0g of refined lecithin, and 5.0g of emodin in refined sesame oil, heat to 80°C respectively, mix well, first emulsify fractionally in a tissue masher, and then The homogenizer emulsifies to meet the particle size of the preparation. Add water for injection to 1000ml, cool, and fill to obtain emodin injection emulsion.

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PUM

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Abstract

The present invention discloses a kind of emodin emulsion for injection. Each 1000 ml of the injection contains emodin 0.2-20.0g, vegetable oil for injection 50-300g, emulsifier 5-20g and isoosmotic regulator 20-60g except water for injection. Its preparation process includes the steps of: dissolving, heating, mixing, emulsifying, cooling, filling, etc. It has the advantages of less toxic reaction and irritation, long medicine acting period, small dosage, etc.

Description

technical field [0001] The invention relates to an emodin emulsion for injection and a preparation method thereof, in particular to an emodin injection emulsion for inhibiting pancreatic enzyme activity, antibacterial, liver and kidney protection, anti-tumor and various inflammations, etc. Preparation. Background technique [0002] Emodin, a derivative of hydroxyanthraquinone, is the most widely distributed anthraquinone substance, mainly found in plants such as Polygonaceae and Rhamnaceae, and in many molds, lichens, higher plants and insects Find. Modern pharmacological tests have shown that emodin has various effects such as inhibiting pancreatic enzyme activity, anti-inflammatory, antibacterial, immune regulation, protecting liver and kidney, anti-oxidation, inhibiting platelet aggregation, and anti-tumor. Preparations with emodin as the main component are widely used clinically, such as rhubarb liquid extract, rhubarb Qingwei pills, rhubarb three flavor tablets, rhuba...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61K9/107A61P1/16A61P13/12A61P29/00A61P35/00
Inventor 欧苏尹爱梅
Owner 欧苏
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