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Emulsion of baicalin for injection and its preparation process

A technology of baicalin and emulsion, applied in the directions of anti-inflammatory agents, antiviral agents, pharmaceutical formulations, etc., can solve the problems of unsustainable drug effect, irritating toxic reaction, difficult production, etc., and achieve medical effect and medical level improvement, The effect of maintaining the activity of the enzyme and prolonging the action time

Inactive Publication Date: 2007-02-07
曾列丹
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The present invention aims to overcome the problems of instability, insolubility and avoidance of first-pass effect, low bioavailability, unsustainable drug effect and high production difficulty of the main drug in the above dosage form, and provide a drug with low toxicity and irritation and high drug effect. Long-time, continuous and targeted low-dose baicalin injection emulsion and preparation method thereof

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Dissolve 22.5g of glycerin, 12.0g of refined soybean lecithin in water for injection, and 15.0g of baicalin in refined soybean oil, respectively heat to about 55°C, mix well, first disperse and emulsify in a tissue masher, and use immediately The tissue masher stirs three times at 8000-12000 rpm to disperse, and then emulsifies through a high-speed homogenizer to meet the particle size of the preparation, that is, the particle size of intravenous emulsions less than 1 μm shall not be less than 80%, and no particles greater than 5 μm shall be detected. particle size, add water for injection to 1000, cool to room temperature, fill, and sterilize to obtain baicalin injection emulsion. This process is 1000 prescriptions, and the production can be expanded, and nitrogen protection is required during the production process.

Embodiment 2

[0052]Dissolve 25.0 g of sorbitol in water for injection, 10 g of refined lecithin, and 20.0 g of baicalin in refined corn oil, heat to 70°C respectively, mix well, first disperse and emulsify in a tissue masher, and then pass through high-speed milk Homogenize and emulsify to meet the particle size of the preparation. Add water for injection to 1000, cool to room temperature, and fill to obtain baicalin injection emulsion.

Embodiment 3

[0054] Dissolve 55.5g of xylitol in water for injection, dissolve 15.0g of refined lecithin, and 50.0g of baicalin in refined sesame oil, respectively heat to 80°C, mix well, first disperse and emulsify in a tissue masher, and then pass through a high-speed The homogenizer emulsifies to meet the particle size of the preparation. Add water for injection to 1000, cool, and fill to obtain baicalin injection emulsion.

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Abstract

The invention relates to an emulsion for injection and preparing process, wherein each 1000ml of the injection comprises the following constituents (by weight parts): baikal skullcap root glycosides 1.0-200.0g, vegetable oil for injection 50-300g, emulsifying agent 5-20g, isotonic conditioning agent 20-60g, and balancing water.

Description

technical field [0001] The invention relates to an emulsion for injection and a preparation method thereof, in particular to a baicalin injection emulsion for antibacterial, antiviral and various inflammations and the preparation method thereof. Background technique [0002] Baicalin is a flavonoid compound extracted from the dry root of Scutellaria baicalensis, a plant of Labiatae. It is one of the main active ingredients of Scutellaria baicalensis, and it is also the main quality control index component of Scutellaria baicalensis and its preparations. According to pharmacological research reports, baicalin It has anti-microbial, anti-allergic, antihypertensive and sedative effects, protects the liver and promotes choleresis. Clinically, baicalin preparations are mostly used for clearing heat and detoxification, antibacterial and anti-inflammatory and other diseases. At present, baicalin is mainly an oral preparation. [0003] The aqueous solution and stability of baicali...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K36/539A61K9/107A61K47/44A61P31/04A61P31/12A61P29/00
Inventor 曾列丹
Owner 曾列丹
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