Supercharge Your Innovation With Domain-Expert AI Agents!

Virus strains

A virus strain and tumor cell technology, applied in the direction of viruses/bacteriophages, genetic material components, biochemical equipment and methods, etc., can solve the problems of reducing the efficiency of lytic replication or infecting human tumor cells

Inactive Publication Date: 2006-11-22
BIOVEX LTD
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since oncolytic treatment of cancer requires efficient replication in normally relatively slow-growing human tumor cells, it is expected that adaptation of laboratory virus strains to growth in specific cultured cells may reduce lytic replication in human tumor cells where optimally possible Efficiency or efficiency of infecting human tumor cells

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Virus strains
  • Virus strains
  • Virus strains

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach

[0098] Oncolytic virus of the present invention

[0099] In one embodiment, the virus of the invention is a modified non-laboratory oncolytic virus. These viruses can be used in oncolytic therapy for cancer. Such viruses infect and replicate within tumor cells and subsequently kill the tumor cells. Thus, such viruses are replication-competent viruses. Preferably they are selectively replicable in tumor cells. This means that they replicate in tumor cells but not in non-tumor cells, or that they replicate more efficiently in tumor cells than in non-tumor cells. The ability to selectively replicate can be determined by the assays described herein for assaying replicative ability and tumor cell killing ability and, if desired, can be analyzed by the statistical techniques enumerated herein.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention provides a herpes virus with improved oncolytic properties which comprises a gene encoding an immunomodulatory cytokine and which lacks a functional ICP34.5 gene and a functional ICP47 encoding gene.

Description

[0001] This application is a divisional application of the Chinese patent application (National Application No. 01806750.6, International Application No. PCT / GB01 / 00229) with the invention and creation name "Virus Strain" filed on January 22, 2001. technical field [0002] The present invention relates to non-laboratory strains of, for example, herpesviruses, such as HSV, which have improved oncolytic and / or gene delivery capabilities compared to laboratory strains. Background technique [0003] Viruses have been proposed or demonstrated, in many cases, to be useful in a wide variety of applications in the fields of bioengineering and medicine. This is due to the unique ability of viruses to enter cells with high efficiency. In such applications this is coupled with viral gene expression and replication and / or expression of inserted heterologous genes. Thus, viruses can either deliver genes (or viral genes or other genes) that can be used for example in gene therapy or vacc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/869A61KA61K48/00C12NC12N7/01C12QC12Q1/02
Inventor R·S·科芬
Owner BIOVEX LTD
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com