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A botanical antibiotic and application thereof

A plant antibiotic and plant technology, applied in the field of antibiotics and its application, can solve the problems of difficult drug use, narrow antibacterial, complex process, etc., and achieve the effect of broad prospects for promotion, development and utilization, and strong bactericidal effect

Active Publication Date: 2006-12-27
山东森科尔生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

my country is the birthplace of herbal medicine. Antibacterial Chinese herbal medicine has played an important role in the process of antibacterial and anti-inflammatory. However, it is necessary to develop these antibacterial Chinese herbal medicines into large-scale and dosage forms. The process is relatively complicated and the cost is high. The spectrum is relatively narrow, some are only effective against Gram-positive bacteria, some are only effective against Gram-negative bacteria, and some are only effective against viruses. Before the pathogen is identified, it is difficult to accurately use the drug
After retrieval, there is no report on the use of Chinese herbal medicines to prepare plant antibiotic products that have obvious killing effects on bacteria, fungi, and viruses

Method used

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  • A botanical antibiotic and application thereof
  • A botanical antibiotic and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Take 50 kg of walnut peels, 30 kg of ebony cores, and 30 kg of orange peels and add them to the retort, heat to 145°C, and keep the temperature constant for 1 hour. Collect the dry distilled liquids in various periods, mix them, let stand for 72 hours, settle and separate, and separate the transparent layer by siphon method. Add the separated transparent layer liquid into the distillation pot, distill at 105°C for 2 hours, and collect the distillate. Add 10% activated carbon to the distillate, heat to 95° C. for 45 minutes, filter, and collect the filtrate. Filtrate is plant antibiotic of the present invention, carries out active ingredient determination with following method.

[0093] Determination of Benzoic Acid Content

[0094] 1. Instruments and reagents

[0095] Instruments: Shimadzu LC---10AD high performance liquid chromatograph, SPD-10A ultraviolet monitor; C---R6A data processor;

[0096] Reagents: Except for benzoic acid, which is chromatographically pure...

Embodiment 2

[0122] Take 50 kg of walnut peels, 35 kg of ebony cores, and 35 kg of orange peels and add them to the retort, heat to 145°C, keep the temperature constant for 1 hour, continue heating to 235°C, keep the temperature constant for 2 hours, and then raise the temperature to 370°C for 1 hour. Collect the dry distilled liquids in various periods, mix them, let stand for 72 hours, settle and separate, and separate the transparent layer by siphon method. Add the separated transparent layer liquid into the distillation pot, distill at 115°C for 2 hours, and collect the distillate. Add 10% activated carbon to the distillate, heat to 95° C. for 45 minutes, filter, and collect the filtrate. The filtrate is the plant antibiotic of the present invention.

[0123] Dilute the filtrate with water at a ratio of 1:3, and make the pH value 4.5 to obtain a disinfectant solution, which can be used for disinfection and sterilization of the environment, air, articles, homes, offices, and skin and m...

Embodiment 3

[0125] Take 50 kg of rubbed skin, 60 kg of hawthorn core, and 30 kg of orange peel and add them to the retort, heat to 120°C for 1 hour, then heat to 200°C for 2 hours, then raise the temperature to 300°C for 1 hour. Collect the dry distilled liquids in various periods, mix them, let stand for 68 hours, settle and separate, and separate the transparent layer by siphon method. Add the separated transparent layer liquid into the distillation pot, distill at 125°C for 2 hours, and collect the distillate. Add 13% activated carbon to the distillate, heat to 95° C. for 45 minutes, filter, collect the filtrate, and the filtrate is the plant antibiotic of the present invention.

[0126] Dilute the filtrate with water at a rate of 1:6, make the pH value 5, and add an appropriate amount of essence to obtain a sterilized air freshener, which can be used for air freshening and disinfection in homes, offices, cars, trains, ship cabins, and engine rooms.

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Abstract

Disclosed is a plant antibiotics, prepared by adding each of plant fruits, seeds, kerns, peels, and shells or a mixture thereof at any weight ratio into a retort, heating to 115-150 DEG C, holding the temperature for 1-2 hours; then elevating the temperature to 200-250 DEG C, holding the temperature for 2-3 hours, then elevating the temperature to 350-450 DEG C, holding the temperature for 1-2 hours; collecting the dry distillation liquid of each period, mixing them, standing for 24-72 hours, waiting for stratification, isolating the transparent layer in the middle by siphon, which is the plant antibiotics disclosed. In the said plant antibiotics, the concentration of phenols is no lower than 0.5mg / ml, counted according to the amount of phenol; the concentration of formic acids is no lower than 1.5mg / ml, counted according to the amount of phenylformic acid; the pH value is 2-3.5 measured with an acidimeter. Disclosed plant antibiotics has application value in fields of medical sterilization, public health prevention and treatment, domestic bird diseases prevention, and foodstuff preservation and seasoning.

Description

technical field [0001] The invention relates to an antibiotic and its application, in particular to a plant antibiotic prepared from Chinese herbal medicine and its application. Background technique [0002] Antibiotics are a class of substances with anti-pathogenic or other activities produced by bacteria, molds or other microorganisms in the course of life. Since penicillin was used clinically in 1940, there have been thousands of types of antibiotics, and hundreds of them are commonly used clinically. They are mainly extracted from the culture fluid of microorganisms or manufactured by synthetic or semi-synthetic methods. Because antibiotics can control more than 95% of the diseases caused by bacterial infection, they are widely used in the prevention and treatment of poultry, livestock, crops and other diseases, and have become the main drug for treating infectious diseases. Antibiotics are also used in food and fruit. save. Although antibiotics have a wide range of us...

Claims

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Application Information

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IPC IPC(8): A01N65/00A01P1/00A61K36/00A61P17/00A23K1/00A23L3/3472A01N65/36A01N65/08A01N65/34A23K10/30A23K10/37A23K20/195A23L27/10
CPCY02P60/87
Inventor 杨先锋张锋
Owner 山东森科尔生物药业有限公司
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