Application of acetylcholine esterase inhibitor medication of Yidancao extractive as cholinomimetic

A technology of motherwort extract and acetylcholinesterase, applied in the directions of drug delivery, drug combination, antitumor drugs, etc.

Inactive Publication Date: 2007-02-21
郝书平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main component of Leonurinine is Leonurinine (Leonurinine, C 10 h 14 o 3 N 2 ), stachydrine and oleic acid, the main components of oleic acid are: linoleic acid (42.62%), linolenic acid (29.93%), oleic acid (20.23%), palmitic acid (5.40%), stearic acid (1.57%) ), etc. In addition, it also contains 17 kinds of amino acids, 24 kinds of mineral elements, and vitamin A-like substances. The oil of Ultimacus is the extract squeezed from the seeds of Utilis, which contains motherwortine, stachydrine and oleic acid. The therapeutic effect of cerulean oil as a drug has not been reported yet

Method used

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  • Application of acetylcholine esterase inhibitor medication of Yidancao extractive as cholinomimetic
  • Application of acetylcholine esterase inhibitor medication of Yidancao extractive as cholinomimetic
  • Application of acetylcholine esterase inhibitor medication of Yidancao extractive as cholinomimetic

Examples

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Embodiment 1

[0090] Embodiment 1: Preparation of motherwort water extract

[0091] Buy motherwort 1000 grams from the market pharmacy, cook the whole herb of motherwort in 3000ml distilled water under reflux for 45 minutes, filter the boiled extract, then freeze-dry the filtrate, and weigh 50 grams of the freeze-dried product in powder form.

Embodiment 2

[0092] The preparation of embodiment 2 motherwort water extract

[0093] Motherwort paste is sold in Chinese pharmacies in the market. The motherwort paste is dissolved in distilled water, stirred, filtered, and the filtrate is freeze-dried to obtain the motherwort water extract.

Embodiment 3

[0094] Embodiment 3 prepares tablet

[0095] Use 0.5 g of motherwort alkali, 95.5 g of cornstarch, and 4 g of magnesium stearate, mix all components uniformly and make 100 tablets. Each tablet contains 5mg of motherwort alkali.

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Abstract

An application of the motherwort's extract including leonurinine, leonurine, general leonurine, leonurine A, cadabine in preparing the medicines as acetylcholinesterase depressant for treating and preventing more than 20 diseases including senile dementia, Parkinson's disease, cardiovascular and cerebrovascular diseases, etc is disclosed.

Description

Technical field: [0001] The invention relates to the use of motherwort extract, in particular to the use of motherwort extract as an acetylcholinesterase inhibitor of a cholinemimetic drug in the field of pharmacy. Background technique: [0002] Motherwort (Leonurus) is a plant of the Labiatae family, formerly known as Chi Wei, traditional understanding and indications: irregular menstruation, dysmenorrhea, amenorrhea, postpartum blood stasis abdominal pain, water species, hematuria, red eyes and swelling, dizziness and pain embolism. Leonurus is the mature fruit of motherwort. It is pungent, sweet and slightly cold in nature and taste. It enters the liver meridian. Its function of promoting blood circulation and regulating menstruation is the same as motherwort. It has the functions of clearing liver and improving eyesight, promoting blood circulation and promoting qi. eye disease. Motherwort extracts include: motherwort granules, motherwort paste, motherwort syrup, mother...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/533A61K9/00A61P25/28A61P25/16A61P25/18A61P9/00A61P1/16A61P17/00A61P35/00
CPCA61K36/533A61P1/16A61P9/00A61P17/00A61P25/16A61P25/18A61P25/28A61P35/00
Inventor 郝书平郝辉肖书雨
Owner 郝书平
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