Wettable hydrogels comprising acyclic polyamides
A cyclopolyamide and hydrogel technology, which is applied in the direction of instruments, prostheses, optical components, etc., can solve the problems that polymers are difficult to dissolve in siloxane, and there is no disclosure of hydrophobic components.
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Embodiment 1
[0200] Contact lenses were prepared from the formulations listed in Table 1 below.
[0201] components
[0202]
[0203] The monomer mixture was degassed by placing it under vacuum for 30 minutes and then used to prepare lenses (Zeonor front curves and poly Acrylic backcurves, 50°C). The lenses were manually demolded and stripped with 70:30 PA:DI water. The lenses were then soaked in the following solutions for the indicated times: 100% IPA (1 hour), 70:30 (by volume) IPA:DI water (1 hour), 10:90 IPA:DI water (1 hour) . DI water (30 minutes). Store lenses in fresh DI water. When touching the lens, it feels very smooth. For turbidity / DCA analysis (Table 2), lenses were autoclaved once (122.5°C, 30 min) in 5.0 mL of wetting solution (borate buffered saline); while for mechanical properties and water content (Table 2), Lenses were autoclaved once in a wetting solution containing 50 ppm methylcellulose.
[0204] characteristics
[0205] The properties ...
Embodiment 2
[0207] Contact lenses were prepared from the formulations listed in Table 3 below.
[0208] table 3
[0209] The monomer mixture was vacuum degassed for 10 minutes and then used to make lenses (Zeonor front curve and polypropylene back curve, 50°C) in a nitrogen box under 4 parallel Philips TL03 lamps (20 minute cure). The lenses were manually demolded and immersed in 30:70 IPA:DI water for 10 minutes. Lenses were stripped with ~1 L of boiling deionized water, then transferred to the wetting solution. The lenses feel very smooth. For DCA analysis, lenses were autoclaved once (122.5°C, 30 minutes) in wetting solution (5.0 mL). The measured advancing contact angle was 45±5°.
Embodiment 4
[0217] A study was conducted to evaluate the relative lubricity of lenses containing PVP (Example 3) relative to lenses containing PVMA (Example 4). Seven subjects were blinded to the lens properties and were provided with 2 vials containing one lens. One bottle contained the lens of Example 3 (containing PVP), and the other bottle contained the lens of Example 4 (containing PVMA). Each subject was asked for a subjective rating of how smoother the lenses felt. All 7 subjects chose the lens of Example 4.
[0218] The dynamic coefficient of friction (COF) of the lenses of Example 3 and Example 4 was measured. Use polished stainless steel as the control surface for measurement, and the test speed is 15cm / s. All measurements are made in the lens' own wetting solution in the package.
[0219] The data in Table 6 show that incorporation of 7% PVMA in silicone hydrogel lenses provided smoother lenses than incorporation of 7% PVP.
[0220] Example
[0221] Table 6 shows...
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