Method of assessing risk of and predisposition to the development of a pathology related to the presence of anti-EPCR antibodies

An autoantibody, antibody technology, applied in receptors/cell surface antigens/cell surface determinants, measuring devices, instruments, etc., can solve problems such as unknown antiphospholipid antibodies

Inactive Publication Date: 2007-04-25
PROYECTO DE BIOMEDICINA CIMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, little is known about the mechanism by which the presence of ant...

Method used

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  • Method of assessing risk of and predisposition to the development of a pathology related to the presence of anti-EPCR antibodies
  • Method of assessing risk of and predisposition to the development of a pathology related to the presence of anti-EPCR antibodies
  • Method of assessing risk of and predisposition to the development of a pathology related to the presence of anti-EPCR antibodies

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Example 1: Application of anti-EPCR autoantibodies as individuals present with high levels of autoantibodies There are markers of risk and susceptibility to associated pathologies

[0063] I. Materials and methods

[0064] patient

[0065] 1. APLS patients and controls

[0066] A total of 43 patients [age 44±11 years (mean age±standard deviation (SD)), 39 females and 4 males] were included in this study, according to the international diagnostic criteria between February 1998 and March 2002 [Wilson WA, Gharavi AE, Koike T, Lockshin MD, BranchDW, Piette JC, Brey R, Derksen R, Harris EN, Hughes GR, Triplett DA, Khamashta MA. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop( Internationally harmonized presentation of the preliminary classification criteria used to define antiphospholipid syndrome: report from an international workshop). Arthritis Rheum. 1999; 42: 13...

Embodiment 2

[0134] Example 2: Detection of anti-EPCR autoantibodies in women with myocardial infarction

[0135] research group : 142 women with myocardial infarction (age 39±5 years, mean±standard deviation) and 142 healthy women (age 39±5 years), paired by age and geographic origin. Classical myocardial infarction risk factors (hypertension, hypercholesterolemia, diabetes, smoking, and oral contraceptives) were studied. Anti-EPCR autoantibodies IgG, IgM and IgA in the plasma samples were analyzed according to the ELISA test method described in "Materials and Methods" (Example 1).

[0136] result : High levels of anti-EPCR autoantibodies, defined as values ​​exceeding the 93rd percentile of the distribution of anti-EPCR antibody levels in the control group, were associated with an increased risk of myocardial infarction. In multivariate analysis, high levels of anti-EPCR antibodies were associated with an adjusted odds ratio (OR) of 3.5 for IgA, with a confidence interval (95% CI)...

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Abstract

The present invention relates to a method for detecting the presence of high levels of autoantibodies against protein C/activated protein C endothelial receptor (EPCR). The invention is characterised in that it comprises in vitro detection and quantification of anti-EPCR autoantibodies in a sample.

Description

technical field [0001] The present invention relates to a method for detecting high levels of autoantibodies against the endoglin C / activated protein C receptor (EPCR) in a sample by detection and in vitro quantification. Background of the invention [0002] autoimmune disease [0003] Autoimmune diseases are characterized by the presence of an immune response in which certain factors induce an immune response against host tissues and the production of abnormal antibodies (autoantibodies) that attack these tissues. These autoimmune diseases include diseases such as antiphospholipid syndrome (APLS), rheumatoid arthritis, systemic lupus erythematosus, systemic autoimmune vasculitis, and the like. [0004] APLS is characterized by vascular thrombosis (venous, arterial, or microvascular) and pregnancy complications (fetal death, preterm labor, or multiple spontaneous abortions) associated with the presence of antiphospholipid antibodies. These antibodies are heterogeneous and...

Claims

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Application Information

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IPC IPC(8): G01N33/564G01N33/566C07K14/705C07K14/70
CPCG01N33/564C07K14/70539G01N33/566
Inventor 何塞·埃米达桑托斯拉蒙·蒙特斯迪亚斯韦罗妮卡·乌尔塔多利纳雷斯
Owner PROYECTO DE BIOMEDICINA CIMA
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