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Ofloxacin solution containing clustered water used for animal

A technology of ofloxacin and hexacyclic water, which is used in the field of veterinary medicine for livestock and poultry bacteria and mycoplasma infection, and broad-spectrum antibacterial drugs, which can solve the problem of short duration of peak blood drug concentration, poor bioavailability and slow release speed. and other problems, to achieve the effects of good bioavailability, reduced diffusion resistance, and improved drug release rate and release amount.

Inactive Publication Date: 2007-05-23
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0027] The above is the existing preparation process and detection method of ofloxacin solution, but the existing ofloxacin solution has problems such as slow release rate, short time for the peak plasma concentration, and poor bioavailability

Method used

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  • Ofloxacin solution containing clustered water used for animal
  • Ofloxacin solution containing clustered water used for animal
  • Ofloxacin solution containing clustered water used for animal

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1: a, select purified water (i.e. pure water) as the raw water, general commercially available qualified pure water, the electrical conductivity is less than 20μs / cm, slowly freeze after standing for several hours, the cooling rate is 2-5 ℃ / cm h, the freezing minimum temperature reaches -30~-50℃, so that the water is fully crystallized, and then thawed. The thawing process is carried out below 10℃, and the melted water is collected and stored in a temperature environment of 4-10℃ in time, that is, get six rings of water;

[0061] b. Take 20 ml of hexacyclic water, add ofloxacin and stir until completely dissolved.

[0062] c. Add six-ring water to a full volume of 40ml

[0063] d. Filter.

[0064] e. Semi-finished products are sent for inspection and determination

[0065] f. Filling of qualified products, the filling capacity is 100±1%.

[0066] g. Packaging tightness inspection.

[0067] h. Packing and packaging.

Embodiment 2

[0068] Embodiment 2: The drug of the present invention has a broad antibacterial spectrum, is effective against Gram-positive bacteria, negative bacteria, some anaerobic bacteria, and mycoplasma, and has the advantages of relatively complete oral absorption, high blood drug concentration, and long half-life. It can be used for bacterial and mycoplasma infection in livestock and poultry. The method of use is mixed drink, 1.5ml / L, consecutive 3-5 days as a course of treatment.

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Abstract

The invention relates to a method for using Levofloxacin Hydrochloride to prepare wide-spectrum antibiosis solution, wherein it uses hexacyclic ring water as carrier that adds frozen hexacyclic ring water into Levofloxacin Hydrochloride solution, to reduce the volume of hydrone group, the viscosity and surface tension, to reduce the expand resistance and accelerate the drug release. The hexacyclic ring water has strong affinity with cell, to improve the treatment effect on animal bacterial and mycoplasma affection.

Description

technical field [0001] The invention belongs to the technical field of veterinary drugs, and relates to a broad-spectrum antibacterial drug prepared from ofloxacin as a raw material, a veterinary drug for bacterial and mycoplasma infection in livestock and poultry and a preparation method thereof. Background technique [0002] Water is the most important component of all organisms, and the water content of organisms is generally more than 60%. Except for dry products, the water content in food is between 65% and 90%. It can be said that water plays an important role in our life. plays a very important role. Water has many special properties, which have attracted people's attention in recent years. For example: the magazine "Jiangxi Chemical Industry" in the fourth issue of 1997, page 34 "Water for Life, Miraculous Water", introduced water with a structure of six water molecules, the so-called "six-ring water", which has the function of promoting health. [0003] "The Hexac...

Claims

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Application Information

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IPC IPC(8): A61K31/5383A61K47/04A61P31/04
Inventor 李旭东鲍恩东苏建东
Owner TIANJIN RINGPU BIO TECH
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