Compositions and methods for modulating connexin hemichannels

a technology of connexin and hemichannel, applied in the field of compositions and methods for modulating connexin hemichannel, can solve the problems of affecting affecting the ability of the body to respond to stress, etc., to achieve good therapeutic capacity and enhance the accuracy and probability of identifying a hemichannel modulating compound
US20070042964A1Inactive Publication Date: 2007-02-22ADTRAN
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
ADTRAN
Publication Date
2007-02-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

Disclosed are compositions and methods for modulating hemichannel function in a cell, tissue or organ. The invention also relates to useful screens for detecting such compounds, particularly those capable of modulating connexin phosphorylation. Further provided are therapeutic methods for preventing or treating conditions impacted by undesired hemichannel function in a mammal such as heart arrhythmia.
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Description

CROSS-REFERENCE TO RELATED APPLICATION

[0001] The present application is a divisional of U.S. patent application Ser. No. 10 / 353,549, filed on Jan. 29, 2003, which is a continuation-in-part of U.S. Provisional Application Ser. No. 60 / 352,717, filed on Jan. 29, 2002, all of which are hereby incorporated by reference.FIELD OF THE INVENTION

[0002] The present invention generally relates to compositions and methods for modulating connexin hemichannels. The invention also relates to useful screens for detecting such compounds. BACKGROUND

[0003] There is recognition that gap junctions are important plasma membrane structures that help cells communicate with their environment. For example, most gap junctions are thought to assist passage of small molecules and ions between interconnected cells. Such movement is believed to exert profound effects on many aspects of cell physiology. Plasma membranes of adjacent cells are believed to include hemichannels, “connexons”, formed by multimeric pro...

Claims

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