136 results about "Heart arrhythmia" patented technology

Analyzes surface electrocardiographic and intracardiac signals to identify and separate electrical activity corresponding to distinct but superimposed events in the heart. Assesses the spatial phase, temporal phase, rate, spectrum and reproducibility of each event to determine uniformity of activation in all spatial dimensions. Uses numerical indices derived from these analyses to diagnose arrhythmias. Uses these indices to determine the location of an arrhythmia circuit, and to direct the movement of an electrode catheter to this location for ablation or permanent catheter positioning. Subsequently, uses these indices to determine whether ablation has successfully eliminated the circuit. Uses variability in these indices from the surface electrocardiogram to indicate subtle beat-to-beat fluctuations which reflect the tendency towards atrial and ventricular arrhythmias.

An heart rhythm monitoring device for a vehicle, which determines whether a driver has an arrhythmia includes a vehicle state determining portion that determines whether the vehicle is stopped; an electrode arranged on a steering wheel in a position where the driver grips the steering wheel; an electrocardiogram waveform obtaining portion that obtains a first electrocardiogram waveform from the electrode; and a signal processing and calculating portion that determines whether the heart rhythm of the driver is erratic based on the first electrocardiogram waveform. When the vehicle is in motion, the signal processing and calculating portion determines whether the heart rhythm of the driver is erratic based on the waveform component that is strong with respect to noise in the first electrocardiogram waveform.

A method is provided for ablation in treatment of heart arrhythmias such as atrial fibrillation that includes positioning a catheter apparatus with multiple electrodes within a cardiac chamber, visualizing the catheter apparatus with an interventional system, navigating the catheter apparatus within the cardiac chamber, and delivering energy to selected electrodes of the catheter apparatus from an external source to ablate heart tissue at select locations. Preferably, the external source is an external patch placed on the patient for the delivery of radio-frequency energy. The electrodes of the catheter apparatus are connected to the patch through a patient interface unit where the interface unit selects the electrodes to which radio-frequency energy is to be delivered. In another aspect of the invention, a system for ablation of heart arrhythmias is provided that has a catheter apparatus with multiple electrodes, an interventional system for visualizing the catheter apparatus within a cardiac chamber, and an external source for delivering energy to selected electrodes of the catheter apparatus within the cardiac chamber to ablate heart tissue. Preferably, the system further includes a digital imaging system for obtaining cardiac image data, an image generation system for generating a 3D model of the cardiac chamber from the cardiac image data, and a workstation for registering the 3D model with the interventional system and for visualizing the catheter apparatus over this registered 3D model upon the interventional system.

A catheter apparatus is provided for use in the treatment of heart arrhythmia having a catheter shaft, a mapping and ablation catheter disposed within the shaft, and a control mechanism coupled to both the shaft and catheter. The catheter shaft includes a main body and a coaxial tip section joined to the main body. The tip section can be rotated about a central axis and curved away from the central axis in a controlled manner. The mapping and ablation catheter can be extended outward from the catheter shaft where it is able to take the form of a pre-stressed curve. The control mechanism controls axial rotation of the tip section, the degree of deflection of the tip section and longitudinal movement of the mapping and ablation catheter with respect to the catheter shaft. Preferably, the mapping and ablation catheter forms a pre-stressed loop when it is fully extended from the catheter shaft.In another aspect of this invention, it provides a method for treatment of a heart arrhythmia having the steps of (1) obtaining cardiac image data from a medical imaging system, (2) creating a 3D model from this cardiac image data, (3) registering the 3D model to an interventional system, (4) positioning a catheter apparatus within a chamber of the heart, (5) displaying the catheter apparatus over the registered 3D model on the interventional system, (6) navigating the catheter apparatus within the heart guided by the registered 3D model, and (7) having the catheter apparatus ablate heart tissue at select locations.

A method is provided for treating a heart arrhythmia having the steps of obtaining cardiac digital data from a medical imaging system utilizing an ECG gated protocol; generating a series of 3D images of a cardiac chamber and its surrounding structures, preferably the left atrium and pulmonary veins, from this cardiac digital data at select ECG trigger points that correspond to different phases of the cardiac cycle; registering these 3D images with an interventional system; acquiring ECG signals from the patient in real-time; transmitting these ECG signals to the interventional system; synchronizing the registered 3D images with trigger points on the transmitted ECG signals to generate a 4D image; visualizing this 4D image upon the interventional system in real-time; visualizing a catheter over the 4D image upon the interventional system; navigating the catheter within the cardiac chamber utilizing the 4D image; and using the catheter to treat the cardiac chamber, preferably with ablation.

A method is provided for treatment of a heart arrhythmia such as atrial fibrillation that includes obtaining cardiac image data using a digital imaging system, generating a 3D model of a cardiac chamber and surrounding structures from such cardiac image data, registering the 3D model with an interventional system, visualizing this registered 3D model on the interventional system, positioning a catheter apparatus within the cardiac chamber, visualizing the catheter apparatus over the registered 3D model of the cardiac chamber upon the interventional system, navigating the catheter apparatus within the cardiac chamber utilizing this registered 3D model, and delivering biological material through the catheter apparatus to heart tissue at select locations within the cardiac chamber. Preferably, the biological material are transplanted cells or antibodies. In another aspect of the invention, a system for treatment of heart arrhythmias is provided that has a digital imaging system to obtain cardiac image data, an image generation system to generate a 3D model of a cardiac chamber and its surrounding structures from this cardiac image data, a workstation to register the 3D model onto an interventional system so that the registered 3D model can be visualized upon the interventional system, and a catheter apparatus to deliver biological material such as transplanted cells or antibodies to heart tissue within this cardiac chamber at certain select locations, the catheter apparatus being visualized upon the interventional system over the registered 3D model.

Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current IKur), methods of using such compounds in the prevention and treatment of arrhythmia and IKur-associated conditions, and pharmaceutical compositions containing such compounds.

A catheter apparatus is provided for use in the treatment of heart arrhythmia having a catheter shaft, a mapping and ablation catheter disposed within the shaft, and a control mechanism coupled to both the shaft and catheter. The catheter shaft includes a main body and a coaxial tip section joined to the main body. The tip section can be rotated about a central axis and curved away from the central axis in a controlled manner. The mapping and ablation catheter can be extended outward from the catheter shaft where it is able to take the form of a pre-stressed curve. The control mechanism controls axial rotation of the tip section, the degree of deflection of the tip section and longitudinal movement of the mapping and ablation catheter with respect to the catheter shaft. Preferably, the mapping and ablation catheter forms a pre-stressed loop when it is fully extended from the catheter shaft. In another aspect of this invention, it provides a method for treatment of a heart arrhythmia having the steps of (1) obtaining cardiac image data from a medical imaging system, (2) creating a 3D model from this cardiac image data, (3) registering the 3D model to an interventional system, (4) introducing a catheter apparatus through an incision into an artery, (5) positioning the catheter apparatus within a chamber of the heart, (6) displaying the catheter apparatus over the registered 3D model on the interventional system, (7) navigating the catheter apparatus within the heart guided by the registered 3D model, and (8) having the catheter apparatus ablate heart tissue at select locations.

Disclosed are compositions and methods for modulating hemichannel function in a cell, tissue or organ. The invention also relates to useful screens for detecting such compounds, particularly those capable of modulating connexin phosphorylation. Further provided are therapeutic methods for preventing or treating conditions impacted by undesired hemichannel function in a mammal such as heart arrhythmia.

This invention provides a compound of the formula (I): or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and the use of such compounds for the manufacture of medicament for gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders, cardiac failure, heart arrhythmia, diabetes and apnea syndrome. These compounds have 5-HT4 receptor agonistic activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans.

The invention relates to a blueberry leaves drink with health function based on the blueberry leaves as main material and its making method, wherein the blueberry leaves contents a great amount of flavonoid with more than 40 physiologically activities of reducing blood sugar and blood fat and resisting arrhythmia, the resisting free radical oxidation ability of the blueberry is not compared with the other anti-oxidizing agent, meanwhile there is great amount proanthocyanidins contented in the blueberry with very good health function to the nervous system for children especially for the pregnant woman conspicuously. The making method is characterized by the following: picking the blueberry leaves with more than 90 days growth; using the technique process of washing, immersing, quick freezing, disintegrating, chilling, extracting with vacuum low-temperature, freezing, filtering, allocating, flash sterilizing and germ-free canned. The invention guarantees not to damage the nutrition and effective and active substances in the material almost, which makes the product have certain health function.

A CT imaging system has a rotatable gantry, a table movable fore and aft through an opening defined within the rotatable gantry, and a controller that incrementally moves a subject disposed on the table through a number of discrete data acquisition positions for the acquisition of physiologically gated CT data. The controller also coordinates acquisition of imaging data from the subject at a first data acquisition position within a physiological cycle of the subject and only advances the subject to a next data acquisition position if the imaging data acquired at the first data acquisition position is deemed acceptable. The controller also detects irregularities and physiological motion of the subject and responsive thereto, suspends data acquisition until the irregularity passes, such as, suspending data acquisition until a next cardiac cycle if a heart arrhythmia is detected.

The invention discloses an application of sichuan lovage rhizome oil by supercritical CO2 extraction method in pharmacy, which can be used for treating vascular nerve cephalalgia, cerebral thrombus, cerebrovascular angiosclerosis, coronary heart diseases, angina pectoris, hypertension, or asomnia, or common cold, or women's dysmenorrheal.

Disclosed is a system for the detection of cardiac events that includes an implanted device called a cardiosaver, a physician's programmer and an external alarm system. The system is designed to provide early detection of cardiac events such as acute myocardial infarction or exercise induced myocardial ischemia caused by an increased heart rate or exertion. The system can also alert the patient with a less urgent alarm if a heart arrhythmia is detected. Using different algorithms, the cardiosaver can detect a change in the patient's electrogram that is indicative of a cardiac event within five minutes after it occurs and then automatically warn the patient that the event is occurring. To provide this warning, the system includes an internal alarm sub-system (internal alarm means) within the cardiosaver and / or an external alarm system (external alarm means) which are activated after the ST segment of the electrogram exceeds a preset threshold.

The invention provides methods and materials for screening for polymorphic variants in ABCB1 and diagnosing altered susceptibilities for drug-induced heart rhythm irregularities based on the same. These methods allow better treatment regimens for using drugs that bind a protein encoded by the ABCB1 and / or induce heart rhythm irregularities such as the anti-cancer drug FK228.

Disclosed is a system for the detection of cardiac events (a guardian system) that includes an implanted device called a cardiosaver, a physician's programmer and an external alarm system. The system is designed to provide early detection of cardiac events such as acute myocardial infarction or exercise induced myocardial ischemia caused by an increased heart rate or exertion. The system can also alert the patient with a less urgent alarm if a heart arrhythmia is detected. Using one or more detection algorithms, the cardiosaver can detect a change in the patient's electrogram that is indicative of a cardiac event within five minutes after it occurs and then automatically warn the patient that the event is occurring. To provide this warning, the guardian system includes an internal alarm sub-system (internal alarm means) within the cardiosaver and / or an external alarm system (external alarm means). If the guardian system is put into a pacemaker, the algorithm can utilize a different analysis of the electrogram depending on whether or not the pacemaker is actually pacing the heart.

The invention provides an ECG signal processing method. ECG signals can be analyzed from a plurality of time-frequency resolutions, and SB-LSTM and TD-CNN are separately utilized to mines the overallfluctuation pattern and local fluctuation pattern of signals from ECG sub-layer signals, and a Sum Rule is finally used for fusing the intermediate classification results of each ECG sub-layer to obtain more accurate and robust classification results. The ECG signal processing method avoids individual differences and intra-individual differences caused by manual classification, and can obtain thestable classification results; and in addition, the ECG signal processing method does not need any expert knowledge, does not need to manually design various features, does not need to perform featureselection processing, does not need to separately construct classifiers, is a typical end-to-end method, and has the characteristics of convenient use, high classification accuracy and the like.

This document provides devices and methods for the treatment of heart conditions. For example, this document provides a percutaneous temporary epicardial pacemaker device and system for treating heart arrhythmia.

A method and system for predicting the onset of heart arrhythmias more accurately observes trends in abnormal or pathologic morphology of the electrocardiogram (ECG). A first set of ECG signals is monitored from a patient. A baseline measurement is generated from the monitored first set of ECG signals to contain nonpathologic ECG morphologies in each lead. A second set of ECG signals is monitored from the patient and the baseline measurement is subtracted from the second set of ECG signals on a beat-to-beat basis. Afterwards, a residuum signal is generated for each lead based on the subtraction. R-wave heterogeneity, T-wave heterogeneity, P-wave heterogeneity, or ST-segment heterogeneity or other indicators of arrhythmia risk or myocardial ischemia are quantified based on the generated residuum signals.

The invention belongs to the medication technical field, which discloses the medicine and the preparation method for treating the coronary heart disease and miocardial infarction. The medicine is mainly prepared from ginseng root, dwarf lilyturf tuber, Chinese magnoliavine fruit, radix astragali and Chinese angelica, or ginseng root, dwarf lilyturf tuber, Chinese magnoliavine fruit, radix astragali, Chinese angelica, cassia twig and liquorice, or ginseng root, dwarf lilyturf tuber, Chinese magnoliavine fruit, radix astragali, Chinese angelica, cassia twig, liquorice, danshen root, red peony root, radix notoginseng and safflower, according to certain ratios of weights. The invention can be made to any type of medicament that can be accepted by the clinic or pharmacology, which is the good quality oral preparation. The medicine has effects of Qi-replenishing, Yin-nourishing and pulse-invigorating and blood circulation activating to dissipate blood stasis and lipid lowing, which can be used to curing the chest distress, hard breathe, heart-throb, angina and arrhythmia caused by coronary heart disease and miocardial infarction, the recovery period of the cerebral thrombosis and the sequelae of the cerebral thrombosis, the effects are obvious.

The invention relates to a drug combination which cures arrhythmia and a production method. The drug combination is produced by red ginseng, epimedium, fructus psoraleae (stir-frying with salt-water), medlar, ma-huang, asarum, salvia miltiorrhiza and bloodsucker. The granule types comprise grain granule, hard capsule granule, soft capsule granule, troche, drop pill, pill and oral liquid preparation. The invention aims at providing a drug curing the arrhythmia, not only has accurate curative effects, but also better improves clinic symptoms, shortens the treatment period and prevents recrudescence.

Disclosed is a system for the detection of cardiac events (a guardian system) that includes an implanted device called a cardiosaver, a physician's programmer and an external alarm system. The system is designed to provide early detection of cardiac events such as acute myocardial infarction or exercise induced myocardial ischemia caused by an increased heart rate or exertion. The system can also alert the patient with a less urgent alarm if a heart arrhythmia is detected. Using one or more detection algorithms, the cardiosaver can detect a change in the patient's electrogram that is indicative of a cardiac event within five minutes after it occurs and then automatically warn the patient that the event is occurring. To provide this warning, the guardian system includes an internal alarm sub-system (internal alarm means) within the cardiosaver and / or an external alarm system (external alarm means). If the guardian system is put into a pacemaker, the algorithm can utilize a different analysis of the electrogram depending on whether or not the pacemaker is actually pacing the heart.

The invention provides traditional Chinese medicine composition for treating depression insomnia. The traditional Chinese medicine composition is prepared from 30-60 parts by weight of spina date seed extract and 30-60 parts by weight of albizia flower extract, wherein the content of saponin in the spina date seed extract is larger than or equal to 85.0%, and saponin has effects of heart nourishing, mind tranquilizing, sedation, hypnosis, arrhythmia resistance and myocardial ischemia resistance, has certain pressure reduction effect and is one of main components with sedative and hypnotic effects, thereby having quite good effect of improving sleep; the total flavonoid content of the albizia flower extract is larger than or equal to 35%, and flavonoid compounds have effects of depression resistance, anxiety resistance, scavenging of hydroxyl radicals and the like and has significant pharmacological activity in aspects of treatment of depression, schizophrenia, cancer and the like. Therefore, spina date seeds and albizia flowers in the formula form a medicine pair, the composition is simple, convenient, effective and economic, has functions of soothing the liver, relieving depression, tranquilizing mind, regulating qi and harmonizing the stomach, and is used for treating emotional disorder, depression insomnia, chest distress, anorexia and the like.

The invention relates to a preparation method for traditional Chinese medicine alkaloid salt and application thereof, in particular to a preparation method for fumitory total alkaloids salt and application of the total alkaloids salt as a medicament for treating cardiovascular diseases. The method solves the problem of poor effect of treating the cardiovascular diseases due to poor water solubility and low bioavailability of the fumitory total alkaloids salt. The preparation method for the fumitory total alkaloids salt comprises the following steps: extracting and purifying fumitory coarse powder to obtain the fumitory total alkaloids, and then carrying out salt-forming reaction between the fumitory total alkaloids and acid to obtain the fumitory total alkaloids salt. The extraction ratio of the fumitory total alkaloids is more than 0.5 percent, and the purity of the obtained fumitory total alkaloids salt is more than 50 percent. The fumitory total alkaloids salt has the advantages that the fumitory total alkaloids salt has good water solubility, has a solubleness more than 60 percent, has high bioavailability, and is used as an effective component for treating the cardiovascular diseases, such as coronary heart disease, angina pectoris, arrhythmia and premature beat.

The invention discloses a Chinese medicament for treating cardiovascular and cerebrovascular diseases, which is prepared from the following raw materials (by weight portions): pericarpium trichosanthis 20-25%, Bulbus Allii Macrostemonis 15-20%, cinnamon twig 15-20%, polygala root 5-7%, radix salvia miltiorrhiza 10-14%, nutgrass flatsedge rhizome 10-12% and dalbergia wood 10-12%. The medicament can be triturated into capsules or prepared into pills through conventional methods.

A method and system for predicting the onset of heart arrhythmias more accurately observes trends in abnormal or pathologic morphology of the electrocardiogram (ECG). A first set of ECG signals is monitored from a patient. A baseline measurement is generated from the monitored first set of ECG signals to contain nonpathologic ECG morphologies in each lead. A second set of ECG signals is monitored from the patient and the baseline measurement is subtracted from the second set of ECG signals on a beat-to-beat basis. Afterwards, a residuum signal is generated for each lead based on the subtraction. R-wave heterogeneity, T-wave heterogeneity, P-wave heterogeneity, or ST-segment heterogeneity or other indicators of arrhythmia risk or myocardial ischemia are quantified based on the generated residuum signals.

The invention relates to the technical field of automatic detection of electrocardiogram signals, and discloses heart beat classification method, device, equipment and storage medium based on U-Net network. The heart beat classification method based on the U-Net network provided by the invention is a new method which is capable of realizing automatic classification of heart beats by adopting a machine learning model based on the U-Net network, and specifically comprises the following steps: designing a U-Net network model of one-dimensional convolution neural network; inputting electrocardiogram data into the U-Net network model so as to be subjected to training and cross validation, thereby obtaining a heart beat classification recognition model; and then, performing heart beat classification on electrocardiogram signals to be tested by using the recognition model, thereby obtaining corresponding heart beat classification results. Therefore, many problems of manual feature extractionand traditional machine learning can be relieved, and model input can be carried out without artificial design or electrocardiogram feature extraction so as to achieve accurate diagnostic results; andthus, the heart beat classification method based on the U-Net network can be widely applied to common arrhythmia detection, thereby facilitating practical application and promotion.

A method is provided for treatment of a heart arrhythmia such as atrial fibrillation that includes obtaining cardiac image data using a digital imaging system, generating a 3D model of a cardiac chamber and surrounding structures from such cardiac image data, registering the 3D model with an interventional system, visualizing this registered 3D model on the interventional system, positioning a catheter apparatus within the cardiac chamber, visualizing the catheter apparatus over the registered 3D model of the cardiac chamber upon the interventional system, navigating the catheter apparatus within the cardiac chamber utilizing this registered 3D model, and delivering biological material through the catheter apparatus to heart tissue at select locations within the cardiac chamber. Preferably, the biological material are transplanted cells or antibodies. In another aspect of the invention, a system for treatment of heart arrhythmias is provided that has a digital imaging system to obtain cardiac image data, an image generation system to generate a 3D model of a cardiac chamber and its surrounding structures from this cardiac image data, a workstation to register the 3D model onto an interventional system so that the registered 3D model can be visualized upon the interventional system, and a catheter apparatus to deliver biological material such as transplanted cells or antibodies to heart tissue within this cardiac chamber at certain select locations, the catheter apparatus being visualized upon the interventional system over the registered 3D model.