Super-sparger microcarrier beads and precision extrusion deposited poly-epsilon-caprolactone structures for biological applications

a technology of polyepsiloncaprolactone and microcarrier beads, which is applied in the field of microcarrier beads, can solve the problems of high cell yield, difficult culture of anchorage dependent cells to commercial yield, and insufficient cell survival
US20080020049A1Inactive Publication Date: 2008-01-24DARLING ANDREW +3
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
DARLING ANDREW
Publication Date
2008-01-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

In on aspect, the invention includes a microcarrier bead having a porous three-dimensional core having (a) a polymeric porous three-dimensional body having porosity of about 15 to about 90% such that at least 99% of pores are interconnected and have diameters of at most 200 microns, (b) an outer protective layer and optionally (c) a filler. In another aspect, the invention includes a method of making an artificial scaffold wherein a scaffolding material is extruded into a coolant and thereby creating a porous material having a porosity of between 15-90% such that at least 99% of pores are interconnected and have diameters of at most 200 microns.
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Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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