Cell/tissue mass selecting apparatus and dividing mechanism thereof
a cell/tissue mass and selecting apparatus technology, applied in the field of cell/tissue mass selecting apparatus, can solve the problems of increased possibility of cell differentiation and contamination, inability of cell subcultruing device to select and cut an appointed area of the cell mass, and inefficient use of time, so as to achieve rapid and precise passing of the cell/tissue.
Active Publication Date: 2010-10-14
IND TECH RES INST
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- Description
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- Application Information
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Benefits of technology
Enables rapid and precise passaging of cell / tissue mass with reduced contamination risk and full utilization of selected areas, improving efficiency over conventional methods.
Problems solved by technology
However, the subculturing procedure is mostly accomplished by manual operation, resulting in inefficient use of time and increased possibility for cell differentiation and contamination.
Method used
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[0018]As shown in FIGS. 1, 2A and 2B, the invention provides a selecting mechanism 10 for selecting cell / tissue mass C, such as human embryonic stem cell colony. The selecting mechanism 10 comprises a base 20, a feeding mechanism 22, a dividing mechanism 2 for dividing the cell / tissue mass C, and an image capturing assembly 30.
[0019]The base 20 has a transparent platform P for placing a carrier D (Petri dish, glass slide and etc.) carried with the cell / tissue mass C. Human embryonic stem cell colony has a diameter about 1 mm to 3 mm. The image capturing assembly 30, disposed in the base 20 and below the platform P, captures the image of the cell / tissue mass C through the platform P. The feeding mechanism 22, disposed on the base 20, moves relative to the platform P in an X direction, a Y direction and a Z direction. The dividing mechanism 23 is disposed on the feeding mechanism 22. When the feeding mechanism 22 moves relative to the platform P, the dividing mechanism 23 is moved sim...
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Abstract
A selecting apparatus for selecting cell / tissue mass includes a base, a feeding mechanism and a dividing mechanism. The base has a platform for placing the cell / tissue mass. The feeding mechanism, disposed on the base, moves relative to the platform. The dividing mechanism, disposed on the feeding mechanism, includes a first cutting set and a second cutting set connected therewith. The second cutting set reciprocally moves between a first position and a second position, toward the first cutting set. The feeding mechanism moves the dividing mechanism above the platform, aligning the dividing mechanism with a portion of the cell / tissue mass, and moves the first cutting set toward the cell / tissue mass, cutting into the portion of the cell / tissue mass. The second cutting set moves from the first position to the second position, limiting the portion of the cell / tissue mass between the first cutting set and the second cutting set.
Description
BACKGROUND OF THE INVENTION[0001]1. Field of the Invention[0002]The invention relates to a cell / tissue mass selecting apparatus, and in particular, to a cell / tissue mass selecting apparatus utilizing a clamping-type dividing mechanism to complete multi procedures such as auto-selecting, cutting and transferring the cell / tissue mass.[0003]2. Description of the Related Art[0004]The cultivation of human embryonic stem is carried out by cultivating a cell mass on feeder cells or extrracellular matrix. When proceeding in subculture, the cell mass is first divided into pieces, and then the selected piece is transferred to new feeder cells or extracellular matrix for further cultivation. However, the subculturing procedure is mostly accomplished by manual operation, resulting in inefficient use of time and increased possibility for cell differentiation and contamination.[0005]A mechanical tool has been disclosed and is utilized for subculturing of cells, such as a cell subculturing device ...
Claims
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IPC IPC(8): C12M1/00
CPCG01N1/06C12M33/04G01N1/2813Y10T83/263Y10T83/283C12M1/26C12M1/268C12M3/00C12M1/00
Inventor CHEN, WANNHSINHSU, LIH-TAOGUU, YEOU-BINCHEN, YU MEI
Owner IND TECH RES INST