Novel antibodies against cancer target block tumor growth, angiogenesis and metastasis

a technology of angiogenesis and metastasis, which is applied in the field of new antibodies against cancer target block tumor growth, angiogenesis and metastasis, can solve the problems of lack of specificity, limited psa screening, and inability to predi

a technology of angiogenesis and metastasis, which is applied in the field of new antibodies against cancer target block tumor growth, angiogenesis and metastasis, can solve the problems of lack of specificity, limited psa screening, and inability to predi

US20110086029A1Inactive Publication Date: 2011-04-14RGT UNIV OF CALIFORNIA
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  • Novel antibodies against cancer target block tumor growth, angiogenesis and metastasis
  • Novel antibodies against cancer target block tumor growth, angiogenesis and metastasis
  • Novel antibodies against cancer target block tumor growth, angiogenesis and metastasis

Examples

Experimental program
Comparison scheme
Effect test

example 1

FACS Analysis Showing Screening of Antibody Clones Targeting the First Extracellular Domain of the N-Cadherin Protein

[0128]FIG. 1 shows recognition of the protein on the surface of prostate cancer cells.

example 2

FACS Analysis Showing Screening of Antibody Clones Targeting the Fourth Extracellular Domain of the N-Cadherin Protein

[0129]FIG. 2 shows that clones recognize N-cadherin on the surface of prostate cancer cells.

example 3

Subcloning of N-Cadherin Antibodies

[0130]FIG. 3 shows that purified monoclonal clones recognize the protein on the cell surface.

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Abstract

The present invention provides antibodies that target the first-third domains of N-cadherein and the fourth domain of N-cadherin, for diagnosis and therapy of cancers related to N-cadherein. Methods of diagnosis and treatment utilizing these antibodies are also described.

Description

CROSS-REFERENCES TO RELATED APPLICATIONS[0001]This application is a continuation-in-part of PCT / US09 / 39526, filed Apr. 3, 2009, which is an application claiming benefit under 35 U.S.C. §119(e) of U.S. Patent Application No. 61 / 042,604, filed Apr. 4, 2008, and U.S. Patent Application No. 61 / 113,054, filed Nov. 10, 2008, each of which is herein incorporated by reference in its entirety.STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT[0002]The present invention was in part supported by NIH / NCI SOMI Training Grant R25 CA 098010 and NIH / NCI UCLA Prostate SPORE, P50 CA 092131. The government has certain rights in this invention.BACKGROUND OF THE INVENTION[0003]Prostate cancer is the most common malignancy and the second leading cause of cancer-related death in American men. Prostate cancer is a biologically and clinically heterogeneous disease. A majority of men with this malignancy harbor slow-growing tumors that may not impact an individual's n...

Claims

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Application Information

Patent Timeline
14 Apr 2011
Publication
US20110086029A1
IPC
A61K39/395; C12N5/12; C07K16/18; G01N33/53; A61P35/00
CPC
A61K2039/505; C07K2316/96; C07K16/2896; C07K2317/73; C07K2317/76; A61P13/08; A61P13/10; A61P35/00
Inventors
REITER, ROBERT E.; WAINBERG, ZEV