Bispecific Anti-her antibodies

a technology of her1 and anti-her antibodies, applied in the field of anti-her antibodies, can solve the problems of affecting the effect of skin toxicity,
US20120121596A1Inactive Publication Date: 2012-05-17F HOFFMANN LA ROCHE & CO AG
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
F HOFFMANN LA ROCHE & CO AG
Publication Date
2012-05-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides anti-HER antibodies, including multispecific anti-HER antibodies, compositions comprising and methods of using these antibodies. Also provided herein are EGFR / HER3 multispecific antibodies that are less toxic than traditional EGFR antagonists.
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Description

RELATED APPLICATIONS

[0001] This application claims the benefit of priority under 35 USC 119(e) of U.S. Provisional Application No. 61 / 210,562, filed Mar. 20, 2009, the disclosure of which is incorporated herein by reference in its entirety.FIELD OF THE INVENTION

[0002] The present invention concerns anti-HER antibodies, including multispecific anti-HER antibodies with binding specificity for at least two different HER receptors, and use of the antibodies to treat diseases or disorders.BACKGROUND OF THE INVENTION

[0003] The HER family of receptor tyrosine kinases are important mediators of cell growth, differentiation and survival. The receptor family includes four distinct members including epidermal growth factor receptor (EGFR, ErbB1, or HER1), HER2 (ErbB2 or p185neu), HER3 (ErbB3) and HER4 (ErbB4 or tyro2).

[0004] EGFR, encoded by the erbB1 gene, has been causally implicated in human malignancy. In particular, increased expression of EGFR has been observed in breast, bladder, lung, head...

Claims

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