Therapeutic calcium phosphate particles in use for aesthetic of cosmetic medicine, and methods of manufacture and use
a technology of cosmetic medicine and calcium phosphate, which is applied in the field of new calcium phosphate core particles for use in aesthetic medicine, can solve the problems of inability to make patents that do not disclose the use of calcium phosphate particles as adjuvants or delivery vehicles for aesthetic medicine or treatments, and difficulty in making particles of this size with any degree of consistency, etc., to achieve the effect of reducing the amount of agents, enhancing the magnitude, quality and/or duration
Inactive Publication Date: 2012-08-16
CAPTIVATE PHARMACEUTICALS LLC
View PDF3 Cites 10 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Benefits of technology
The calcium phosphate core particles enhance the efficacy and stability of administered agents, providing extended bioavailability and reduced dosage requirements, while improving skin appearance and treating various aesthetic and cosmetic conditions through controlled release and biocompatibility.
Problems solved by technology
Particles of this size are difficult to make with any degree of consistency, and their morphology is not described in any detail.
None of these patents disclose the use of nanoparticles as sustained release matrices.
Furthermore, these patents do not disclose the use of calcium phosphate particles as either adjuvants or delivery vehicles for aesthetic medicine or treatments.
There has been a suggestion in the literature to use calcium phosphate particles as vaccine adjuvants, but calcium phosphate particles have generally been considered an unsuitable alternative to other adjuvants due to inferior adjuvanting activity.
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreExamples
Experimental program
Comparison scheme
Effect test
example
[0028]A 12.5 mM solution of CaCl2 is prepared (for example, by mixing 1 to 2 g of CaCl2 into 800 mL of sterile GDP water under aseptic conditions until completely dissolved, and diluting it to 1 L, and then filtering). A 15.625 mM solution of sodium citrate is then prepared (for example, by dissolving 0.919 g of sodium citrate into 200 mL of sterile GDP water with mixing using aseptic techniques and filtered). Then, a 12.5 mM solution of dibasic sodium phosphate is prepared (for example, by dissolving 1.775 g sodium phosphate into 1 L of sterile GDP water with mixing using aseptic techniques and filtered). All solutions were stored at room temperature.
[0029]The calcium chloride solution is combined with the sodium citrate solution and thoroughly mixed. The sodium phosphate solution is then added with mixing. Turbidity appears as particles began to form. In certain embodiments, the particles may be used by themselves (as fillers), which will be described in more detail below. In othe...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
| Property | Measurement | Unit |
|---|---|---|
| diameter | aaaaa | aaaaa |
| size | aaaaa | aaaaa |
| diameter | aaaaa | aaaaa |
Login to View More
Abstract
Calcium phosphate (“CAP”) particles for use in cosmetic, nutraceutic or aesthetic medicine. The particles may be used as carriers for cosmetic, nutraceutic or a factors, as controlled release matrices for the material, and as fillers in cosmetic treatments. The particles may be applied topically or injected or by any other appropriate delivery method.
Description
BACKGROUND OF INVENTION[0001]This application claims the benefit of U.S. patent application Ser. No. 60 / 623,958, filed Nov. 1, 2004, the entire contents of which are hereby incorporated by reference.[0002]1. Field of the Invention[0003]The present invention relates to novel calcium phosphate core particles for use in aesthetic medicine, to methods of making them, and to methods of using them in corrective or cosmetic surgery, as filler, for the sustained release of cosmetic medicines, and as a delivery vehicle for pharmaceutical agents, nutraceuticals, growth factors, and / or tissue repair chemicals and biochemicals.[0004]2. Description of Related Art[0005]Nanometer scale particles have been proposed for use as carrier particles, as supports for biologically active molecules, such as proteins, and as decoy viruses. See U.S. Pat. Nos. 5,178,882; 5,219,577; 5,306,508; 5,334,394; 5,460,830; 5,460,831; 5,462,750; and 5,464,634, the entire contents of each of which are hereby incorporated...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & AuthorityApplications(United States)
IPC IPC(8): A61K8/24A61Q19/00A61K8/02
CPCA61K8/24A61Q19/08A61Q19/00A61K8/0245A61K8/36A61K8/66A61K8/671A61K8/676A61K8/678A61K8/73A61K8/85A61K8/981A61K2800/10A61K2800/651
InventorBELL, STEVE J.D.
OwnerCAPTIVATE PHARMACEUTICALS LLC