Detection of chromosomal abnormalities associated with endometrial cancer

a chromosomal abnormality and endometrial cancer technology, applied in the field of endometrial hyperplasia and carcinoma detection, can solve the problem of difficult diagnosis of endometrial cancer, and achieve the effect of stable hybridization

Inactive Publication Date: 2014-01-30
MAYO FOUND FOR MEDICAL EDUCATION & RES +1
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Despite it aggressiveness, endometrial cancer is difficult to diagnose, thus many patients present with symptoms of the late-stage cancer.

Method used

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  • Detection of chromosomal abnormalities associated with endometrial cancer
  • Detection of chromosomal abnormalities associated with endometrial cancer
  • Detection of chromosomal abnormalities associated with endometrial cancer

Examples

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example 1

Array CGH Studies

[0210]Study Design

[0211]In a collaborative study of Abbott Molecular and Mayo Clinic carried out in 2007-2009, fresh-frozen, biopsy from proven endometrial carcinoma specimens from 62 patients were obtained with informed consent at the time of surgery from Rochester Methodist Hospital at Mayo Clinic, Rochester, Minn. Serial 5-μm sections were cut from the collected tissue and sections were stained with hematoxylin and eosin (H&E) for histological analysis. Specimens with greater than 70% tumor were selected for aCGH analysis and remaining sections were left unstained for future clinical studies.

[0212]DNA from the selected specimens was extracted and amplified prior to CGH analysis by the GenoSensor™ system. Vysis GenoSensor DNA microarray slides obtained from Abbott Molecular (Des Plaines, Ill.) were used for CGH analysis. The microarray slides contained 287 DNA targets consisting of known oncogenes, tumor suppressor genes, and regions of gain, loss, or loss of hete...

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Abstract

The methods and compositions described herein address the need for diagnostic method that could be offered to women during yearly checkups to allow for early detection, diagnosis and classification, and treatment of endometrial cancer. In addition, these methods and compositions address the current need for improving diagnostic accuracy of biopsy procedures in symptomatic patients.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. application Ser. No. 13 / 068,451, filed May 10, 2011, which claims the benefit of U.S. provisional application No. 61 / 395,303, filed May 10, 2010, which are hereby incorporated by reference in their entireties.FIELD OF THE INVENTION[0002]The present invention relates generally to the area of detecting, diagnosing, and monitoring of endometrial hyperplasia and carcinoma.BACKGROUND OF THE INVENTION[0003]Uterine cancer is the fourth most common malignancy diagnosed in women in the United States (estimated 42,793 cases in 2009) and is the seventh most common cause of cancer death among U.S. women. Over 95% of all uterine cancers are cancers of the endometrium (lining of the body of the uterus). Lifetime probability of developing cancer of the uterus is 1 in 40 (U.S.). 35-50% of women ages 35-70 present with one or more risk factors for endometrial cancer.[0004]Two different clinicopathologic subtypes ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12Q1/68
CPCC12Q1/6886C12Q2600/156C12Q1/6837C12Q1/6841C12Q2600/118
Inventor PESTOVA, EKATERINAMORRISON, LARRYVOSS, JESSE S.PETERSON, LISA M.HALLING, KEVIN C.
Owner MAYO FOUND FOR MEDICAL EDUCATION & RES
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