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Application of longhu rendan in preparing medicament for preventing and/or treating liver fibrosis

Inactive Publication Date: 2019-09-12
SHANGHAI ZHONGHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is about using a plant called Longhu Rendan to make medicine for preventing and treating liver fibrosis. Longhu Rendan can significantly improve fibrosis and has the same effects as a positive drug called silybin. It also has fewer side effects and is safer. The results from the testing showed that even at low and medium concentrations, Longhu Rendan can significantly improve fibrosis and has the same effects as silybin.

Problems solved by technology

If liver fibrosis is not treated in time, it eventually develops into cirrhosis.
At present, there is no effective therapeutic agent for treatment of liver fibrosis.
Liver fibrosis is usually treated with chemical drugs, but chemotherapy has low safety, high toxicity, and high cost, as well as a large side effect on the human body.

Method used

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  • Application of longhu rendan in preparing medicament for preventing and/or treating liver fibrosis
  • Application of longhu rendan in preparing medicament for preventing and/or treating liver fibrosis
  • Application of longhu rendan in preparing medicament for preventing and/or treating liver fibrosis

Examples

Experimental program
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Effect test

example 1

[0018]Experimental animals: SPF grade C57 mice, 8-week old, half male and half female, supplied by Guangdong Medical Lab Animal Center, housed in an animal room in a barrier environment (SPF grade), and feeds and water and libitum. Certificate [SCXK(YUE) 2013-0002].

[0019]The experimental agents and reagents used in the experiment are shown in Table 1:

TABLE 1Experimental agents and reagentsMaterialLot numberManufacturerSodiumC830BA0009Sangon Biotech (Shanghai)carboxymethylcelluloseCo., Ltd.Longhu Rendan160108Shanghai ZhonghuaPharmaceutical Co., Ltd.Silybin capsule550609055Tianjin Tianshili ShengtePharmaceutical Co., Ltd.CCl4E1422028Aladdin

[0020]The experimental apparatuses are shown in Table 2:

TABLE 2Experimental apparatusesApparatusModelManufacturerElectronic balanceB604028467Mettler-ToledoInstruments(Shanghai) Co., Ltd.PhotomicroscopeX51OlympusUltra-clean workbenchBCM-1000Suzhou Antai (China)

[0021]Experimental Design

[0022]Administration: 32 pills of Longhu Rendan were placed in a m...

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Abstract

An application of Longhu Rendan in preparing a medicament for preventing and / or treating liver fibrosis The Longhu Rendan has significant effect in improving liver fibrosis, and its effect in anti-liver fibrosis and liver protection is equivalent to those of a positive drug silybin.

Description

BACKGROUND OF THE INVENTION1. Field of the Invention[0001]The present invention relates to preparation of medicaments for liver fibrosis, and in particular, application of Longhu Rendan in the preparation of a medicament for preventing and / or treating liver fibrosis.2. Description of Related Art[0002]Liver fibrosis is a ubiquitous injury repair response in various chronic liver injury processes, and its main feature is the massive deposition of extracellular matrix (ECM). If liver fibrosis is not treated in time, it eventually develops into cirrhosis. In addition, liver fibrosis is also considered to be an important cause of liver cancer. Liver fibrosis can be reversed by timely and rational intervention. At present, there is no effective therapeutic agent for treatment of liver fibrosis. Liver fibrosis is usually treated with chemical drugs, but chemotherapy has low safety, high toxicity, and high cost, as well as a large side effect on the human body. Therefore, it has become a ho...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K36/899A61K36/28A61K36/484A61K36/9064A61K36/61A61K31/045A61K36/534A61K36/79A61K36/54A61K36/67A61K47/12A61K47/02A61K47/36A61K47/34A61P1/16
CPCA61K31/045A61K47/36A61K36/484A61K36/9068A61K36/61A61P1/16A61K36/54A61K47/34A61K47/02A61K36/534A61K47/12A61K36/79A61K36/28A61K36/9064A61K36/67A61K36/899A61K36/285A61K36/48A61K36/57A61K9/2059A61K2300/00
Inventor JIN, JIAHUAWANG, BIYEDING, LIQINCAO, WUJIEZHU, XIAOPINGLAN, TIAN
Owner SHANGHAI ZHONGHUA PHARMA
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