Composition for treating atopy or pruritus containing n-acetyl or n-acylamino acid

Inactive Publication Date: 2020-10-08
STEMDR +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent is about a composition that can prevent, improve, or treat skin issues like atopy and pruritus using a specific type of acid. The composition is safe and effective, and can be used for a range of causes without causing any harm. Overall, this patent offers a natural and effective way to address common skin issues.

Problems solved by technology

However, not all types of pruritus are associated with the mediating substances, and pruritus caused by mechanical stimulation, electrical stimulation or skin dryness may occur regardless of mediating substances.
Because the symptoms last long and do not heal well, long-term patient treatment is necessary.
However, the symptoms are ameliorated with age.
The cause of pruritus and atopic dermatitis is unclear in many cases and, despite the presence of various therapeutic agents including steroids, the therapeutic effect is only temporary or limited.
In addition, the steroid drugs have side effect problems associated with misuse or abuse.

Method used

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  • Composition for treating atopy or pruritus containing n-acetyl or n-acylamino acid
  • Composition for treating atopy or pruritus containing n-acetyl or n-acylamino acid
  • Composition for treating atopy or pruritus containing n-acetyl or n-acylamino acid

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Test Animals and Reagents

[0107]7-week-old male Balb / c mice and 7-week-old male Nc / Nga mice were purchased from Orient Bio (Seongnam, Gyeonggi-do, Korea) and maintained under specific pathogen-free conditions. The mice were housed in an air-conditioned animal room at a temperature of 25±1° C. and a relative humidity of 40±5%, and they were given distilled water and laboratory diet. Animal treatment and maintenance complied with the Principles of Laboratory Animal Care (NIH Publication No. 85-23, revised in 1985) and the guidelines of the Institutional Animal Care and Use Committee of the Jeonbuk National University (KHUASP (SE)-15-021). All procedures were conducted in accordance with the guidelines of the United States National Institute of Health (NIH).

Induction of Atopic Dermatitis

[0108]In order to induce atopy-like dermatitis in Balb / c mice, DNFB sensitization was induced by applying 100 μL of 0.35% 2,4-dinitrofluorobenzene (DNFB) (Sigma, USA) in acetone / olive oil (3:1) on the ...

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Abstract

The present disclosure relates to a composition for preventing, alleviating or treating pruritus and / or atopy using an N-acetylamino acid or an N-acylamino acid having almost no side effects on the human body. Also, the present disclosure relates to a cosmetic composition for moisturizing skin or soothing skin. The composition of the present disclosure may be utilized to ameliorate a problematic skin condition caused by various causes, or to safely and effectively alleviate or treat pruritus and / or atopy without concern about side effects.

Description

TECHNICAL FIELD[0001]The present disclosure relates to a composition for preventing or treating atopy, pruritus or atopy accompanied by pruritus, moisturizing skin or soothing skin, which contains an N-acetyl or N-acylamino acid as an active ingredient.BACKGROUND ART[0002]Pruritus (itch) is defined as an unpleasant sensation that causes the desire to scratch or rub skin (Andersen H H et al., Human surrogate models of histaminergic and non-histaminergic itch, Acta Dermato-Venereologica. 95 (7): 7717. (2015)). Although it is a symptom commonly observed in skin diseases and systemic diseases, its characteristics are not fully known yet.[0003]It is known that about 280 million people globally, 4% of the world population, have difficulty with pruritus, with higher incidence than psoriasis (2-3%) (Vos, T et al., Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010, Lancet. 380 (9859):...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61K31/405A61K8/49A61K8/44A61K8/02A61P17/04A61Q19/00A23L33/175A23L33/00
CPCA23L33/40A23L33/175A23V2002/00A61P17/04A61Q19/007A61K31/198A61K31/405A61K8/0212A61K8/442A61K8/4913A61K8/44A61K8/492A61K2800/75A61Q19/00A61P17/00A61K31/197A23V2200/318A23V2250/06A23L33/10
Inventor HAN, MYUNG-KWAN
Owner STEMDR
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