Antimicrobial adhesive composition with copper nanoparticles for dentures
a technology of adhesive composition and copper nanoparticles, which is applied in the direction of biocide, impression caps, transportation and packaging, etc., can solve the problems of poor cleaning habits, general discomfort, and unpleasant taste of dentures, and achieves the effects of reducing the number of patients, and reducing the number of dentures
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example 1
1. Example 1
Obtaining CuNPs
[0042]Copper nanoparticles (CuNPs) can be obtained using well known technologies (Madhulika Bhagat et. al., Review—Multifunctional Copper Nanoparticles: Synthesis and Applications, ECS Journal of Solid State Science and Technology, 2021, 10, 063011).
[0043]Alternatively, enveloped CuNPS in ceramic material particles can be prepared. For that, zeolite particles (nanoporous crystalline aluminosilicate) and silica nanoparticles were used as support materials, using natural zeolite of national origin (MOR) and commercial 100 nm silica nanoparticles. CuNPs are formed on site in the material, whereby a certain MOR mass was contacted with a 0.1 M copper acetate solution for 24 h at room temperature. Once the ion exchange period was completed, the zeolite was separated and washed by repeated centrifugation / dispersion cycles. The resulting material was then dispersed in a starch / ascorbic acid reducing solution and microwaved for a few seconds.
[0044]This system for t...
example 2
2. Example 2
Preparation of the Antimicrobial Denture Adhesive Composition Containing CuNPs
[0045]25 g of mineral oil (w / w) and 28.4 g of petrolatum (w / w) are mixed at 60° C. under a stirring speed of 300 ppm for 10 minutes. Next, 0.071 g of copper nanoparticles (w / w) are added and the mixture is stirred at the same temperature for 10 minutes. Next, 31.6 g of PVM / MA (w / w) and 14.9 g of carboxymethylcellulose are added (w / w), and the resulting mixture is stirred for 40 minutes at 60° C. The product obtained is allowed to cool to room temperature.
[0046]In order to compare the chemical structure of the antimicrobial denture composition with CuNPs with known denture adhesives in the market, adhesives were analyzed by using total attenuated reflectance with Fourier transform infrared spectroscopy (ATR-FTIR) in an Agilent Cary 630 ATR-FTIR spectrometer.
[0047]FIG. 1 shows the results of said ATR-FTIR analysis, which evidences that the denture adhesive modified with CuNPs have the same spectr...
example 3
3. Example 3
In-Vitro Assessment of the Antimicrobial Properties of the Antimicrobial denture adhesive composition containing CuNPs
[0049]Antimicrobial properties of the denture adhesives were assessed against Candida albicans, pathogen responsible of denture stomatitis disease, by using the agar disk-diffusion method. Filter paper discs of 6 mm in diameter were impregned with the denture adhesives for 20 minutes. After that, 100 μL of 0.5 Mcfarland (1-5×106 CFU / ml) of ATCC 90029 strain of Candida albicans were seeded on plates of Sabouraud dextrose agar medium. Then, adhesive—impregnated disks were placed onto the surface of the inoculated agar plate. Each disk was pressed down to ensure complete contact with the agar surface, and they were distributed evenly so that they were no closer than 24 mm from center to center. The plates were incubated at 37° C. under aerobic conditions for 48 hours after which the disks were applied. Plates were examined after 48 h of incubation (FIG. 3). ...
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