2 results about "Lymphocyte transformation" patented technology

This invention belongs to the field of plant extract technology, specifically relating to a plant extract composition for enhancing immunity. By weight, it is composed of the following raw materials: 3-5 parts Astragalus membranaceus extract, 2.5-4 parts Echinacea purpurea extract, and 1.5-3.5 parts Rhodiola rosea extract. This plant extract composition, through the scientific formulation of Astragalus membranaceus, Echinacea purpurea, and Rhodiola rosea, and an enzymatic extraction process, enhances the immunomodulatory effect. The combination of the three extracts increases the secretion of TNF-α and IL-6 by macrophages. Furthermore, the spleen lymphocyte stimulation index (SI) of the three extracts reaches 5.57, and the lymphocyte transformation rate increases from 191% to 457%. These results indicate that this plant extract composition effectively enhances the body's non-specific and cellular immune functions by activating macrophages and promoting T lymphocyte proliferation through multiple pathways, providing more comprehensive immune protection.

This invention provides a 3D-printed hydrogel loaded with mare's milk-derived exosomes, exhibiting pro-inflammatory and antioxidant properties, along with its preparation method and applications, belonging to the field of wound dressing technology. The mare's milk-derived exosomes (M-Exo) of this invention possess excellent pro-inflammatory effects, promoting the high expression of cellular pro-inflammatory factors IL-12p40 and TNF-α, and effectively killing microorganisms in infected wounds. This invention utilizes silk fibroin peptides to encapsulate M-Exo, resulting in drug-loaded nanofiber crystals that serve as a ROS-responsive nano-drug delivery system for M-Exo. When the microenvironment of an infected wound highly expresses ROS, the silk fibroin peptide nanofiber crystals dissolve, releasing M-Exo, thereby increasing T lymphocyte transformation rate, rapidly killing wound microorganisms, and accelerating wound healing.