The invention relates to the technical field of skin staplers, and discloses a stapler with quick reset, comprising a casing, a handle and a nail seat, the handle is movably connected inside the casing, and one end of the handle is fixedly equipped with a downward pressure One end of the lower pressure rod is movably connected with a nail-pressing rod, one end of the nail-pressing rod is fixedly equipped with a nail-pressing plate, the bottom of the casing is fixedly equipped with a nail base, and the nail base is fixedly equipped with a sterilizing device. A safety post and a return spring are fixedly installed on the upper end face of the handle, and a safety device and a quick reset device that cooperate with the safety post and the return spring are fixedly installed on the inner top of the casing. The safety device includes a safety body, a conical block, a telescopic A rod and a second return spring, the quick return device includes an L-shaped plate, a fixed shaft, a movable frame, a roller and a telescopic spring. The invention can realize the functions of secondary sterilization, stapler insurance and quick reset after nailing out.