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Enteric coated Chinese medicine composition for treating cervical and lumbar spondylopathy

An enteric coating, lumbar spondylosis technology, used in drug combination, drug delivery, bone diseases, etc., can solve problems such as gastrointestinal adverse reactions and irritation of the stomach

Active Publication Date: 2008-07-02
JIANCHANGBANG CHINESE HERBAL MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the problem that the above-mentioned traditional Chinese medicine stimulates the stomach, the present invention has developed an enteric coating composition suitable for the medicine, and uses the composition to coat the traditional Chinese medicine, which solves the problems of adverse reactions in the gastrointestinal tract and the like

Method used

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  • Enteric coated Chinese medicine composition for treating cervical and lumbar spondylopathy
  • Enteric coated Chinese medicine composition for treating cervical and lumbar spondylopathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. Preparation of methacrylic acid copolymer enteric-coated tablets

[0024] (1) Preparation of traditional Chinese medicine for treating cervical and lumbar spondylosis

[0025] Prepare the following Chinese medicinal materials: Shenjincao 80g, Myrrha 53g, Dipsacus 80g, Pueraria 53g, Frankincense 53g, Dogji 80g, Achyranthes bidentata 53g, Safflower 53g, Paeoniae Alba 213g, Peach kernel 53g, Rehmannia glutinosa 53g, Licorice 26.5g ;

[0026] Among the above 12 herbs, take 168g of Radix Paeoniae Alba, grind it into fine powder, add the remaining Radix Paeoniae Alba and the remaining 11 herbs to decoct twice, for 1.5 hours for the first time, and 1 hour for the second time, combine the filtrates, filter, The filtrate is concentrated under reduced pressure to an extract with a relative density of 1.1-1.2 (50° C.), mixed with the above-mentioned fine powder, dried into a dry paste, and pulverized to obtain a traditional Chinese medicine for tableting.

[0027] (2) Prepara...

Embodiment 2

[0050] 1. Preparation of hypromellose phthalate enteric-coated granules

[0051] (1) Preparation of traditional Chinese medicine for treating cervical and lumbar spondylosis

[0052] Prepare the following Chinese medicinal materials: Shenjincao 75g, Myrrha 50g, Dipsacus 75g, Pueraria 50g, Frankincense 50g, Dogji 75g, Achyranthes bidentata 50g, Safflower 50g, Paeoniae Alba 200g, Peach kernel 50g, Rehmannia glutinosa 50g, Licorice 25g;

[0053] Add water to the above-mentioned twelve ingredients and decoct three times, the first time for 1.5 hours, the second and third times for one hour each, filter, combine the filtrates, and concentrate under reduced pressure to a relative density of 1.30-1.45 (measured at 50°C). Clear the ointment and get the traditional Chinese medicine.

[0054] (2) Preparation of particles

[0055] Use 300g of traditional Chinese medicine obtained in step (1), 500g of lactose, 550g of sucrose, 10g of sweet orange powder essence, 100g of hypromellose RT-...

Embodiment 3

[0075] 1. Preparation of shellac-coated traditional Chinese medicine enteric-coated pellets and capsules

[0076] (1) Preparation of traditional Chinese medicine for treating cervical and lumbar spondylosis

[0077] Same as Example 1.

[0078] (2) Preparation of pill core

[0079] Use 300g of traditional Chinese medicine, 150g of microcrystalline cellulose, and 50g of lactose to make 1000 capsules.

[0080] The drug is mixed with auxiliary materials, and the soft material is made by adding appropriate amount of water, and extruded into strips with the same diameter through an extrusion sieve plate (1mm). Enter the spheronizer to make the granules completely spheroidized, dry at 60 degrees Celsius, and take 18-24 mesh pellets for coating.

[0081] (3) Preparation of coating solution

[0082] Use shellac 375g, Tween 8020g, triethyl citrate 20g, castor oil 20ml, appropriate amount of 95% ethanol to make 2000ml coating solution.

[0083] (4) Coating

[0084] Coating with a f...

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Abstract

The present invention belongs to the field of coated composition technology, and is especially enteric coated Chinese medicine composition for treating wind-cold-damp arthralgia. The enteric coated composition is either water dispersed preparation comprising enteric soluble release-controlling agent, plasticizer, surfactant and water, or organic solution comprising enteric soluble release-controlling agent and organic solvent. The enteric coated composition has less adverse gastrointestinal tract reaction and obviously raised curative effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine coating composition, more specifically, the invention relates to a traditional Chinese medicine enteric coating composition capable of reducing adverse stimulation of the gastrointestinal tract and increasing curative effect for treating cervical and lumbar spondylosis. Background technique [0002] Cervical and lumbar spondylosis are common and frequently-occurring diseases in orthopedics. The etiology of cervical and lumbar spondylosis mostly belongs to the category of arthralgia caused by traditional Chinese medicine. "Su Wen. Arthralgia Theory": "The wind, cold, and dampness are mixed together, and they are numbness. Those who win the wind are the paralysis of movement; those who win the cold are the numbness of pain; those who win the dampness are the numbness." There is also: "Bi If it is in the bones, it will be heavy; if it is in the veins, the blood will not coagulate; if it is in the m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61K9/00A61P19/08
Inventor 杨晓穗
Owner JIANCHANGBANG CHINESE HERBAL MEDICINE CO LTD
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