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Composite stent material, composite stent and production method thereof

The technology of a composite bracket and its production method is applied in the field of medical engineering and can solve problems such as easy loosening and blockage

Active Publication Date: 2008-07-09
BEIJING ALLGENS MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

200410062260.8 discloses a multi-layer composite degradable stent, but since the polymer materials degraded at different speeds are degraded into blocks, when the supporting force of the undegraded polymer materials is not strong, it is easy to loosen and collapse, and finally form a block together

Method used

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  • Composite stent material, composite stent and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 prepares support (polylactide (100,000) / nylon)

[0022] 1. Nylon wire with a diameter of 0.001mm is woven into a mesh;

[0023] 2. Dissolve polylactide (molecular weight: 100,000) in dichloromethane to form a solution with a mass volume concentration of 0.000001g / ml, and stir evenly;

[0024] 3. The net in step 1 is laid on the bottom of the mold, and the solution in step 2 is poured into the mold. Let the solution evaporate to form a film with a thickness of 0.1. Cut the film into strips with a width of 6mm;

[0025] 4. Wind the strips in step 2 into a spiral shape on the mold, and set the shape at 35° C. for 48 hours to make a spiral stent.

Embodiment 2

[0026] Embodiment 2 prepares support (silk fibroin / silicone rubber)

[0027] 1. Dissolve silk fibroin material in water, prepare a 5g / ml solution, and stir evenly;

[0028] 2. Spread the silicone rubber wire with a diameter of 0.02mm on the bottom of the mold, and pour the solution into the mold. Let the solution evaporate to form a film with a thickness of 2mm. Cut the film into strips with a width of 0.1mm;

[0029] 3. Wind the strips in step 2 into a spiral shape on the mold, and set the shape at 50° C. for 1 hour to make a spiral stent.

Embodiment 3

[0030] Example 3 Preparation of scaffold (copolymer of glycolide and lactide (100,000) / poly-β-hydroxybutyrate valerate (100,000))

[0031] 1. Make poly-β-hydroxybutyrate valerate (molecular weight 100,000) into filaments with a diameter of 0.02mm.

[0032] 2. Dissolve the copolymer of lactide and lactide (molecular weight 100,000, monomer ratio 1:1) in dichloromethane, make a solution with a mass volume concentration of 0.001g / ml, and stir evenly;

[0033] 3. Pour the solution into the mold, and after 15 hours of volatilization, put the silk in step 1 into the mold. Allow the solution to evaporate completely to form a film with a thickness of 0.2mm. Cut the film into strips with a width of 1.5mm;

[0034] 4. Wind the strips in step 3 into a spiral shape on the mold, and set the shape at 40° C. for 20 hours to make a spiral stent.

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Abstract

The invention discloses a composite rack material and manufacturing method, which is made of different decomposing macromolecular material or non-decomposable macromolecular material, wherein the non-decomposable macromolecular material displays yarn-shape or net shape as frame, which is attached on the frame; the composite rack is cut into long bar, which is winded on the mould to form spiral shape to shape under 20-80 deg.c for 0.1-48h; the composite rack material generates little chip in vivo, which is exhausted through biliary tract or urine without blocking pipe.

Description

[0001] The present invention is a divisional application of application number 2005100117798. [0002] The name of the original application is: composite scaffold material, composite scaffold and its production method; [0003] The applicant is Beijing Aojing Pharmaceutical Technology Co., Ltd. technical field [0004] The invention relates to the technical field of medical engineering, in particular to a biomedical composite material. Background technique [0005] In clinical practice, cases of ductal stenosis in humans are frequently encountered. Such as urethral stricture, biliary stricture and so on. Urethral stricture is a fairly common histological abnormality in men, often secondary to infectious disease or injury of the urethra. The pathogens of urinary tract infection can spread to the prostate at the same time, causing inflammation of the prostate; due to the fibrotic urethral stricture formed after urethral injury, it can lead to dysuria and urine reflux. Bili...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04A61L31/14A61F2/88
Inventor 崔菡孟波
Owner BEIJING ALLGENS MEDICAL SCI & TECH