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Water aqua containing clindamycin for treating acne

A technology for clindamycin and clindamycin hydrochloride, which is applied to the field of liquid preparations containing clindamycin, can solve the problems of acne patients not being able to insist on taking medication, low curative effect on acne, and achieving simple ingredients and convenient use. Effect

Inactive Publication Date: 2009-01-07
梁树宏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some clindamycin detergents simply dissolve clindamycin in a solvent, which is not effective for the acne caused by the first and second reasons above.
In addition, clindamycin often produces a strong odor over time, which is not acceptable for topical medications applied to the patient's face
The above-mentioned disadvantages are that acne patients cannot adhere to medication

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] A clindamycin-containing lotion for the treatment of acne, consisting of the following ingredients:

[0012] Clindamycin Hydrochloride 3%

[0013] Alcohol 25%

[0014] Glycerin 0.21%

[0015] Propylene Glycol 0.75%

[0016] Methylparaben 0.15%

[0017] Propylparaben 0.05%

[0018] water balance

[0019] The clindamycin hydrochloride has the functions of killing Corynebacterium acnes and anti-inflammatory.

[0020] Alcohol is used as the main solvent to dissolve various components without adding a pH regulator, and can maintain the stability of clindamycin hydrochloride; alcohol can also clean the sebum on the skin surface, allowing clindamycin hydrochloride to penetrate into the hair follicle duct epithelium Inside; in addition, the present invention has used alcohol of higher concentration, and it also has the effect of certain anti-inflammation and disinfection.

[0021] Glycerin dissolves the main ingredients completely; moisturizes and moisturizes the skin; r...

Embodiment 2

[0029] A clindamycin-containing lotion for the treatment of acne, consisting of the following ingredients:

[0030] Clindamycin Hydrochloride 1%

[0031] Alcohol 22%

[0032] Rosewater 0.1%

[0033] Glycerin 0.1%

[0034] Propylene Glycol 0.25%

[0035] Methylparaben 0.1%

[0036] Propylparaben 0.14%

[0037] Distilled water balance

[0038] Rose extract makes the product fragrant, and has the functions of moisturizing, anti-wrinkle, whitening, softening, astringent and soothing, anti-aging, deep cell replenishment, preventing skin dryness, and promoting female hormone secretion. Jasmine or lavender extract can be substituted for rose extract.

[0039] The effect of all the other ingredients is identical with embodiment 1.

[0040] The clindamycin-containing aqueous agent used for treating acne described in this example has a delicate fragrance, which can be used to treat acne, and also allows patients to feel a fresh fragrance. It can be made into a spray water agent,...

Embodiment 3

[0044] A clindamycin-containing lotion for the treatment of acne, consisting of the following ingredients:

[0045] Clindamycin Hydrochloride 3.5%

[0046] Alcohol 25%

[0047] Rosewater 0.45%

[0048] Glycerin 2%

[0049] Propylene Glycol 1%

[0050] Methylparaben 0.22%

[0051] Propylparaben 0.01%

[0052] Distilled water balance

[0053] The mode of use is the same as in Example 1.

[0054]Adopt the product described in this embodiment to treat 100 acne patients, so that after 1 week, 85 patients have obvious curative effect, and after 2 weeks, 95 patients are cured, and the cure rate reaches 95%. During the course of medication, 11 patients developed allergies or rashes, which disappeared naturally 3 days after stopping the medication.

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PUM

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Abstract

The invention discloses a water solution containing chlorolincomycin for treating acne which comprises the following ingredients (by weight portion): clindamycin hydrochloride 1-3.55, ethanol 22-25%, glycerin 0.1-2%, methyl glycol 0.25-1%, methyl-p-hydroxybenzoate 0.1-0.22%, propyl-p-hydroxybenzoate 0.01-1.14%, and balancing pure water.

Description

technical field [0001] The invention designs a clindamycin-containing liquid preparation for treating acne. Background technique [0002] Acne is a common skin disease, and some severe patients can seriously affect the appearance. At present, it is believed that the etiology and pathogenesis of acne have four points: 1. Exuberant secretion of skin glands; research has found that the amount of androgen precursors in the blood of patients with severe acne increases significantly, leading to hyperfunction of sebum and excessive sebum generation. 2. Hair follicle duct epithelial hyperplasia, excessive keratinocytes are formed, and the change of intercellular substance makes keratinocytes firmly adhere to each other, then mixes with sebum and cells, and blocks the hair follicle opening, forming "acne". 3. Microbial infection: mainly Corynebacterium acnes (Propionibacterium), followed by P. ovale and Staphylococcus albus. 4. Inflammatory reaction: Propionibacterium acnes is an a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/7056A61P17/10
Inventor 梁树宏
Owner 梁树宏
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