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Oral resveratrol multi-phase liposome and preparation method thereof

A multi-phase liposome, resveratrol technology, applied in the direction of liposome delivery, hydroxyl compound active ingredients, drug combination, etc., can solve the problem of unsatisfactory clinical effect, low bioavailability, resveratrol, etc. Difficulty and other problems, to achieve the effect of preventing and treating tumor diseases, good compliance, and simple preparation process

Inactive Publication Date: 2009-01-21
李万忠 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although resveratrol is a promising drug for tumor prevention and treatment, it is poorly absorbed in the body due to its poor solubility in water, instability to light, and limitations of its own physical and chemical properties. The bioavailability is not high, and the clinical effect is not ideal

Method used

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  • Oral resveratrol multi-phase liposome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1: oral multiphase liposome of resveratrol, said liposome is made up of following components: resveratrol, lecithin, cholesterol, polyvinylpyrrolidone, Tween-80, phosphate buffered saline;

[0048] The weight percentage of each composition of described liposome is:

[0049] Resveratrol 6%

[0050] Lecithin 10%

[0051] Cholesterol 10%

[0052] Polyvinylpyrrolidone 0.2%

[0053] Tween-80 0.6%

[0054] Phosphate buffered saline 73.2%;

[0055] The preparation method of resveratrol oral multiphase liposome comprises the following steps:

[0056] (1) Take lecithin, cholesterol and Tween-80 according to the proportion, and dissolve them in ethanol to obtain an ethanol solution for subsequent use;

[0057] (2) Then dissolve resveratrol and polyvinylpyrrolidone in phosphate buffer solution in proportion, keep warm at 50°C, stir at a constant temperature, and slowly add ethanol solution to the end, and continue stirring for 60 minutes to make all ethanol volati...

Embodiment 2

[0059] Embodiment 2: oral multiphase liposome of resveratrol, the liposome is composed of the following components: resveratrol, soybean lecithin, cholesterol, hydroxypropyl cellulose, Tween-85, phosphate buffered saline;

[0060] The weight percentage of each composition of described liposome is:

[0061] Resveratrol 7%

[0062] Soy Lecithin 8%

[0063] Cholesterol 8%

[0064] Hypromellose 0.3%

[0065] Tween-85 1%

[0066] Phosphate buffered saline 70%;

[0067] The preparation method of resveratrol oral multiphase liposome comprises the following steps:

[0068] (1) Take soybean lecithin, cholesterol and Tween-85 according to the proportion, and dissolve them in ethanol to obtain ethanol solution for subsequent use;

[0069] (2) Then dissolve resveratrol and hydroxypropyl cellulose in phosphate buffer solution in proportion, keep warm at 60°C, stir at a constant temperature, and slowly add ethanol solution to the end, continue stirring for 75min, so that all ethanol i...

Embodiment 3

[0071] Example 3: Oral multiphase liposome of resveratrol, the liposome is composed of the following components: resveratrol, lecithin, cholesterol, hydroxypropyl cellulose, Tween-80, and phosphate buffer solution.

[0072] The weight percentage of each composition of described liposome is:

[0073] Resveratrol 9%

[0074] Lecithin 14%

[0075] Cholesterol 14%

[0076] Hypromellose 0.5%

[0077] Tween-80 1.5%

[0078] Phosphate buffered saline 61%.

[0079] The preparation method of resveratrol oral multiphase liposome comprises the following steps:

[0080] (1) Take lecithin, cholesterol and Tween-80 according to the proportion, and dissolve them in ethanol to obtain an ethanol solution for subsequent use;

[0081] (2) Then dissolve resveratrol and hydroxypropyl cellulose in phosphate buffer solution in proportion, keep warm at 70°C, stir at a constant temperature, and slowly add ethanol solution to the end, continue stirring for 90min, so that all ethanol volatilizes ...

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Abstract

The invention discloses an oral polyphase liposome of resveratrol, wherein the ingredients of the liposome include resveratrol, phosphatidy icholine, soybean lecithin, cholesterin, polyvinylpyrrolidone, hydroxypropylcellulose, Twain-80 or Twain-85, and phosphonate buffer solution. The oral preparation has the advantages of better adaptability for patients and simpler preparing process.

Description

technical field [0001] The invention relates to an antitumor drug, in particular to an oral multiphase liposome of resveratrol and a preparation method thereof. Background technique [0002] Tumor is a common and frequently-occurring disease, which poses a great threat to people's life and health. It is a research topic that has received more and more attention in the medical field. In many large cities in China, malignant tumors have surpassed cardiovascular and cerebrovascular diseases, ranking first among all causes of death, and in the age group of 35 to 59, tumors have always been the number one killer. In the past, many severe infectious diseases that seriously threatened people's life and health have been controlled, the average life expectancy has been gradually extended, and diagnostic technology has been continuously improved. bit. [0003] At present, tumor treatment includes surgery, radiotherapy and chemotherapy, mainly chemotherapy. The compliance of surgery...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K31/05A61P35/00
Inventor 李万忠
Owner 李万忠
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