A method for preparing medicinal compounds with amoxicillin sodium and potassium clavulanate

A technology of potassium clavulanate and amoxicillin sodium, applied in the field of pharmaceutical preparation, can solve the problems of poor mixed powder fluidity, drug contamination, difficulty in aseptic sub-packaging, etc., and achieves good product fluidity, good post-processing performance, granular uniform effect
CN100464750CActive Publication Date: 2009-03-04ZHUHAI UNITED LAB
3 Cites 5 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHUHAI UNITED LAB
Publication Date
2009-03-04

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The present invention relates to a method for preparing medicine mixture containing amoxicillin sodium and potassium clavulunate. Said method includes the following processes: (a), dissolving two medicine active components in solvent according to a certain ratio so as to form a solution; (b), mixing said solution with supercritical fluid; and (c), separating out medicine micropowder from supercritical fluid. Said medicine granules have good fluidity.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the field of medicine preparation, in particular to a method for preparing a drug mixture containing amoxicillin sodium and clavulanate potassium. Background technique

[0002] Most of the pharmaceutical compositions containing two or more antibiotics are mixed products of dry powder. In order to ensure the uniformity of the drug content in the preparation, each component needs to be pulverized, sieved, etc., so that the components in the composition can be mixed evenly . Due to the differences in particle size, density, morphology and surface state and surface energy between the different components, the mixing process is difficult, and the mixed materials can also be separated again during the conveying process. Conventional production methods for uniformly mixing two or more drugs into granules or mixed powder include mechanical grinding, freeze drying, spray drying and the like. However, there are considerable defects in ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More