Use of alkaloid for preparing antineoplastic medicine

Abstract

The invention discloses the use of alkaloids for preparing antitumor drugs. There are two kinds of alkaloids, and the structural formula of the alkaloids that can be used for preparing antitumor drugs is as follows: it has the advantages of remarkable antitumor activity and the like.

Description

technical field

[0001] The invention relates to the use of antitumor drugs, in particular to alkaloids with antitumor effects. Background technique

[0002] Malignant tumor is a disease that seriously endangers human life. Its mortality rate is second only to cardiovascular and cerebrovascular diseases, and its incidence is increasing year by year. Now there are surgery, radiotherapy and drug therapy methods for tumor treatment, among which drug therapy has positive, positive and irreplaceable effects in tumor treatment or comprehensive treatment, prolonging the life of tumor patients and improving their quality of life. Antineoplastic drugs have been able to cure or control many tumor types, but the overall level has not yet reached a satisfactory stage. Therefore, it is of great significance to research and develop drugs with effective antitumor activity. Obtaining active ingredients from natural plants and using them as lead compounds is one of the important ways to res...

Examples

Embodiment Construction

[0013] The antineoplastic drug alkaloid of the present invention is 1-isoquinolinone alkaloids, which are two kinds of compound A and compound B, which are based on "Science Bulletin", 2006, volume 51, phase 7, page 792-795] literature [two Strain South China Sea mangrove endophytic fungus mixed fermentation produces new alkaloid marinamide and its methyl ester] described preparation method, that is: use GYP as medium to mix and ferment and cultivate two strains of marine fungi (the strain numbers are №1924 and №3893, the bacteria The silk is soaked and extracted with ethanol, and the extract is prepared by silica gel column chromatography, eluted with ethyl acetate and then eluted with 9:1 ethyl acetate-methanol.

[0014] The MTT reduction method detects compound A and compound B antitumor activity test as follows;

[0015] 1).Material:

[0016] 1).1 DMEM / F12 (DF12) medium, trypsin, newborn calf serum, DMSO; compound A and compound B were dissolved in DMSO, diluted to the re...

technical field

[0001] The invention relates to the use of antitumor drugs, in particular to alkaloids with antitumor effects. Background technique

[0002] Malignant tumor is a disease that seriously endangers human life. Its mortality rate is second only to cardiovascular and cerebrovascular diseases, and its incidence is increasing year by year. Now there are surgery, radiotherapy and drug therapy methods for tumor treatment, among which drug therapy has positive, positive and irreplaceable effects in tumor treatment or comprehensive treatment, prolonging the life of tumor patients and improving their quality of life. Antineoplastic drugs have been able to cure or control many tumor types, but the overall level has not yet reached a satisfactory stage. Therefore, it is of great significance to research and develop drugs with effective antitumor activity. Obtaining active ingredients from natural plants and using them as lead compounds is one of the important ways to res...

Examples

Embodiment Construction

[0013] The antineoplastic drug alkaloid of the present invention is 1-isoquinolinone alkaloids, which are two kinds of compound A and compound B, which are based on "Science Bulletin", 2006, volume 51, phase 7, page 792-795] literature [two Strain South China Sea mangrove endophytic fungus mixed fermentation produces new alkaloid marinamide and its methyl ester] described preparation method, that is: use GYP as medium to mix and ferment and cultivate two strains of marine fungi (the strain numbers are №1924 and №3893, the bacteria The silk is soaked and extracted with ethanol, and the extract is prepared by silica gel column chromatography, eluted with ethyl acetate and then eluted with 9:1 ethyl acetate-methanol.

[0014] The MTT reduction method detects compound A and compound B antitumor activity test as follows;

[0015] 1).Material:

[0016] 1).1 DMEM / F12 (DF12) medium, trypsin, newborn calf serum, DMSO; compound A and compound B were dissolved in DMSO, diluted to the re...

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