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Method for preparing potassium aspartate

A technology of potassium aspartate and aspartic acid, which is applied in the chemical field, can solve the problems of potential safety hazards, low efficiency, and high related substances of preparation products, so as to improve production efficiency and product quality, reduce production costs, and increase product yields. rate effect

Active Publication Date: 2009-10-21
西藏中卫诚康药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the actual production of this method, there are long preparation cycle, low efficiency, and low product yield. The general yield is lower than 70%, especially in large-scale production.
As in CN 1439629A uniquely involved in the L-aspartate potassium raw material preparation example 1, the described L-aspartate potassium preparation process will increase the yield (such as 70%) will increase a very large amount of ethanol or the amount of methanol, and will inevitably greatly increase the production cost, and a large increase in the amount of ethanol or methanol will affect the feasibility of actual production
[0017] The difference between the present invention and the traditional spray-drying method (i.e. the reaction solution of potassium salt and aspartic acid, the dry powder prepared by the spray-drying process) is that the method of the present invention is solvent crystallization, and the traditional spray-drying process can be more efficient Potassium aspartate raw material is obtained, but it also has the problem of being unable to effectively remove the impurities introduced by the raw material, the pH value of the product is unstable, the content ratio of potassium and aspartic acid is unstable, and the related substances are relatively high. bring security risks

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Add 1340 milliliters of purified water in the flask, add 56.1 grams of potassium hydroxide under stirring, after all dissolve, add 133.1 grams of L-aspartic acid. After the addition, reflux for 2 hours, and adjust the pH of the solution to 6.0-8.0 with potassium hydroxide and aspartic acid. After filtration, about 80% of the solvent (water) was evaporated from the filtrate under reduced pressure, and the obtained viscous substance was added into 1340 ml of ethanol at -40° C. under stirring, and a large amount of solids were formed while stirring. After adding, let stand for 1 hour. Centrifuge and dry under reduced pressure at 50°C to obtain 181.3 g of potassium L-aspartate, with a yield of 96.3%. The structure of the potassium L-aspartate prepared in this example was confirmed and consistent with that reported in the literature.

Embodiment 2

[0030] Add 1400 milliliters of purified water in the flask, add 69.1 grams of potassium carbonate under stirring, then slowly add 133.1 grams of L-aspartic acid. After the addition, reflux for 2 hours, and adjust the pH of the solution to 6.0-8.0 with potassium hydroxide and aspartic acid. After filtration, about 70% of the solvent (water) was evaporated from the filtrate under reduced pressure, and the obtained viscous substance was added into 1400 ml of ethanol at -80° C. under stirring, and a large amount of solids were formed while stirring. After adding, let stand for 1 hour. Centrifuge and dry under reduced pressure at 50°C to obtain 179.0 g of potassium L-aspartate, with a yield of 95.1%. The structure of the potassium L-aspartate prepared in this example was confirmed and consistent with that reported in the literature.

Embodiment 3

[0032]Add 1200 milliliters of purified water in the flask, add 100.1 grams of potassium bicarbonate under stirring, then slowly add 133.1 grams of L-aspartic acid. After the addition, reflux for 2 hours, and adjust the pH of the solution to 6.0-8.0 with potassium hydroxide and aspartic acid. After filtration, about 85% of the solvent (water) was evaporated from the filtrate under reduced pressure, and the obtained viscous substance was added into 1200 ml of -60°C ethanol with stirring, and a large amount of solids were formed while stirring. After adding, let stand for 1 hour. Centrifuge and dry under reduced pressure at 50°C to obtain 183.1 g of potassium L-aspartate with a yield of 97.3%. The structure of the potassium L-aspartate prepared in this example was confirmed and consistent with that reported in the literature.

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Abstract

A method for preparing potassium aspartate, which belongs to the field of chemistry, is mainly characterized in that potassium salt and aspartic acid are added to water, so that part or all of the water is removed after the reaction, and the residue is added to a water-miscible non-aqueous Compared with the prior art, the method of precipitating a solid in a solvent, crushing and drying to obtain a finished product has the advantages of significantly increasing product yield, reducing production cost, improving production efficiency and product quality, and the like.

Description

technical field [0001] The invention relates to a preparation method of chemical raw materials, in particular to a preparation method of potassium aspartate, belonging to the field of chemistry. Background technique [0002] Potassium aspartate is the potassium salt of aspartic acid and is an electrolyte supplement. Aspartic acid is the precursor of oxaloacetate in the body, plays an important role in the tricarboxylic acid cycle, promotes energy metabolism, and is a catalyst for the synthesis and decomposition of high-energy phosphate compounds; participates in the production of nucleotides, and is an important substance for cell repair and regeneration ; Can promote the excretion of bile and bile pigment, have the effects of jaundice, reduce liver fat, increase liver glycogen, etc.; promote the development and differentiation of T lymphocytes into mature T lymphocytes, and have antiviral and antitumor effects. At the same time, aspartic acid also participates in the ornit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C229/24C07C227/00A61K31/198A61K9/08A61P3/12
Inventor 黄少林胡军刘烽张勇
Owner 西藏中卫诚康药业有限公司
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