Single surface identing surface plasma biochemical sensor
A surface plasmon and biochemical sensor technology, which is applied in the field of biochemical sensing and detection, can solve the problems of low refractive index sensitivity, low sensing sensitivity, and large full-width half-height value, and achieve high sensing sensitivity and measurement accuracy, and high refractive index sensitivity. Great effect with low environmental requirements
Inactive Publication Date: 2010-01-20
INST OF OPTICS & ELECTRONICS - CHINESE ACAD OF SCI
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However, the full width at half maximum of the resonance curve of these sensors is very large (50-100nm), and the sensitivity of the refractive index is small, only 10-30nm / RIU, making the quality factor only 0.1-0.5 or even smaller, so the sensing sensitivity is extremely low; However, some such as surface plasmon biochemical sensors with double-sided grooved structure, although their quality factor has reached a high level (≥40), due to the great difficulty of production, it is not easy to popularize and apply due to the need for double-sided nanoscale alignment grooves, etc.
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[0023] Such as figure 1 , 2 As shown, the present invention consists of an illuminator 1, a light-transmitting optical fiber 2, a sensor detection box 3, an illumination beam finishing system 4, a sample to be tested 6, a single-sided grooved nano-grating substrate 7, a detection optical system 9, a single Colorimeter 10, photomultiplier tube 11, digital converter 12, computer 13, detection box cover 14 and sample chamber small cover 15. The illuminator 1 is connected to the sensor detection box 3 through the optical fiber 2, and the photomultiplier tube 11 is placed at the light output end of the monochromator 10 to receive the sensing detection light, and passes through the monochromator 10 and the light output end of the sensor detection box 3 Connected, the detection box cover 14 is covered on the sensor detection box 3, the illumination beam arrangement system 4 and the detection optical system 9 are sealed in the sensor detection chamber 301 in the sensor detection box ...
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Abstract
A single-face carving groove surface plasma biochemical sensor includes a lighter, a light transmission optical fiber, a sensing detection box, an illuminating beam sorting system, measured sample, a nano grating substrate, a detection optical system, a monochromator, a photomultiplier, a numeral converter, and computer. The measured sample is coated on the nano grating substrate, an illuminating light transmitted by the lighter and the light transmission optical fiber is emitted into the sensing detection box and sorted by the illuminating beam sorting system to illuminate the measured sample, the nano grating substrate coated with measured sample generates surface plasma resonance and local surface plasma resonance, reflected light passes through the detection optical system and the monochromator, is received by the photomultiplier and conversed to magnified electric signal, the electric signal is conversed to digital signal and is sent to the computer to detect species of biochemical sample. Advantages of the invention are: high sensing sensitivity, simple structure, convenient adjustment and use, and easy application.
Description
technical field [0001] The invention is a surface plasma biochemical sensor with grooves on one side, belonging to the technical field of biochemical sensing and detection. Background technique [0002] With the in-depth study of plasmonic optics and the advancement of nanostructure processing technology, the plasmonic properties of metal nanostructure surfaces have been applied. According to the found electromagnetic field can excite the free electrons on the surface of the metal nanostructure to resonate, for a certain incident light frequency range, the coupling of the light and the surface free electrons produces resonance, and there is a strong near-field localization and spectral selective absorption. The change of the refractive index of the medium around the structure is very sensitive, and the use of this characteristic has been applied in biochemical sensing and detection. At present, not only according to the shape and array of certain particles, but also through...
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IPC IPC(8): G01N21/55G01N21/41G06F19/00G01N21/552
Inventor李海颖陈旭南
OwnerINST OF OPTICS & ELECTRONICS - CHINESE ACAD OF SCI