Superparamagnetism magnetic resonance contrast medium, and its preparing method

Abstract

A superparamagnetic MRI contrast medium is a Fe3O4 nanoparticl coated by polyol moleculae. Its preparing process includes such steps as high-temp reaction of Fe contained compound in polyol solution, cooling, depositing, separating, dispersing it in water, filtering, and sterilizing. It has high crystalline level, high saturated magnetic intensity and high imaging effect.

Description

technical field [0001] The invention relates to a magnetic resonance contrast agent and a preparation method thereof. Background technique [0002] Magnetic resonance imaging (Magnetic Resonance Imaging, MRI) is the most important advanced medical imaging technology developed after the 1980s. It has outstanding advantages such as high resolution, multiple imaging parameters, and safe use. has great application potential. Initially, the necessity of using magnetic resonance imaging contrast agents was not recognized in routine clinical diagnosis of diseases. Later, it was found that the relaxation times of some different tissues or benign and malignant tumors overlapped each other, making MRI diagnosis difficult to distinguish. Therefore, it is necessary to use imaging contrast agents to improve the sensitivity and specificity of MRI diagnosis. Contrast agent is an imaging-enhanced contrast agent used to shorten imaging time and improve imaging contrast and clarity. It can ...

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Problems solved by technology

[0003] The purpose of the present invention is to solve the problems of complex synthesis process, high manufacturing cost, large particle size, low crystallinity, low saturation magnetization, poor MRI imaging effect and uneven thickness of the surface coating layer of the existing contrast agent, and provide A kind of superparamagnetic magnetic resonance contrast agent and preparation method thereof

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