Superparamagnetism magnetic resonance contrast medium, and its preparing method

A magnetic resonance contrast agent and superparamagnetic technology, which can be used in pharmaceutical formulations, preparations for in vivo tests, emulsion delivery, etc., can solve the problems of uneven surface coating thickness, complex contrast agent synthesis process, and MRI imaging effects. To achieve the effect of uniform and controllable size, good MRI imaging effect and easy control

Inactive Publication Date: 2007-07-25
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to solve the problems of complex synthesis process, high manufacturing cost, large particle size, low crystallinity, low saturation magnetization, poor MRI imaging effect and uneven thickness of the surface coating layer of the existing contrast agent, and provide A kind of superparamagnetic magnetic resonance contrast agent and preparation method thereof

Method used

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  • Superparamagnetism magnetic resonance contrast medium, and its preparing method
  • Superparamagnetism magnetic resonance contrast medium, and its preparing method
  • Superparamagnetism magnetic resonance contrast medium, and its preparing method

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specific Embodiment approach 1

[0011] Embodiment 1: In this embodiment, the superparamagnetic magnetic resonance contrast agent is iron ferric oxide nanoparticles coated with polyol molecules on the surface, and the diameter of the particles is 1-20 nanometers.

specific Embodiment approach 2

[0012] Specific embodiment two: In this embodiment, the polyol molecule is ethylene glycol molecule, propylene glycol molecule, isopropylene glycol molecule, glycerol molecule, diethylene glycol molecule, triethylene glycol molecule, tetraethylene glycol molecule or a molecular weight M≤4000 Polyethylene glycol molecule. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0013] Embodiment 3: In this embodiment, the diameter of the superparamagnetic magnetic resonance contrast agent particles is 4-10 nanometers. Others are the same as in the first embodiment.

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Abstract

A superparamagnetic MRI contrast medium is a Fe3O4 nanoparticl coated by polyol moleculae. Its preparing process includes such steps as high-temp reaction of Fe contained compound in polyol solution, cooling, depositing, separating, dispersing it in water, filtering, and sterilizing. It has high crystalline level, high saturated magnetic intensity and high imaging effect.

Description

technical field [0001] The invention relates to a magnetic resonance contrast agent and a preparation method thereof. Background technique [0002] Magnetic resonance imaging (Magnetic Resonance Imaging, MRI) is the most important advanced medical imaging technology developed after the 1980s. It has outstanding advantages such as high resolution, multiple imaging parameters, and safe use. has great application potential. Initially, the necessity of using magnetic resonance imaging contrast agents was not recognized in routine clinical diagnosis of diseases. Later, it was found that the relaxation times of some different tissues or benign and malignant tumors overlapped each other, making MRI diagnosis difficult to distinguish. Therefore, it is necessary to use imaging contrast agents to improve the sensitivity and specificity of MRI diagnosis. Contrast agent is an imaging-enhanced contrast agent used to shorten imaging time and improve imaging contrast and clarity. It can ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K49/10
Inventor 蔡伟万家齐
Owner HARBIN INST OF TECH
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