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Fingerprint of Sinisan decoction and establishing method therefor

A method for establishing a method and a technology for standard fingerprints, which are applied to fingerprints, HPLC standard fingerprints of Sinisan decoction and its establishment field, and can solve problems such as unreported

Inactive Publication Date: 2007-08-01
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Pharmacodynamic studies have found that the decoction of the traditional Chinese medicine compound Sini powder has a sedative and hypnotic effect, and has unique curative effects in improving sleep and improving sleep quality, but there are no reports on the material basis of its effect on improving sleep

Method used

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  • Fingerprint of Sinisan decoction and establishing method therefor
  • Fingerprint of Sinisan decoction and establishing method therefor
  • Fingerprint of Sinisan decoction and establishing method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 The establishment of the HPLC standard fingerprint of Sini San water decoction

[0047] 1. Preparation of decoction of Sini powder

[0048] 1 material

[0049] Bupleurum: It is Bupleurum chinense DC. It was purchased from Kangxinyi Medicinal Materials Store, Anguo City, Hebei Province. Origin: Shaanxi

[0050] Radix Paeoniae Alba: Paeonia lactiflora pall, a plant of Ranunculaceae, was purchased from Harbin Shiyitang Traditional Chinese Medicine Pieces Factory, place of origin: Hangzhou. Batch number: 0501052S

[0051] Citrus aurantium (burn): it is Citrus aurantium L., a plant of Rutaceae, purchased from Harbin Shiyitang Traditional Chinese Medicine Pieces Factory, place of origin: Fujian. Batch number: 0412033Ch

[0052] Licorice (burned): Glycyrrhiza uralensis Fisch, a leguminous plant, was purchased from Shiyitang Traditional Chinese Medicine Pieces Factory in Harbin, origin: Inner Mongolia. Batch number: 0412078M

[0053] 2 sample preparation

[00...

experiment example 2

[0142] Experimental example 2 The fingerprint of the present invention is used to analyze the chemical composition changes in the decoction process of Sini powder

[0143] 1. Test materials

[0144] 1 test equipment

[0145] SHIMADZU Japan Shimadzu 2010-A High Performance Liquid Chromatograph

[0146] B3200S-T Ultrasound Oscillator (Branson Ultrasound Shanghai Co., Ltd.)

[0147] METTLER AE240 electronic analytical balance (Switzerland)

[0148] 2 Chromatographic conditions

[0149] kromasil, C 18 (4.6mm×250mm, 5μm)

[0150] C 18 Guard column (Dalian Yilite Analytical Instrument Co., Ltd.) Flow rate: 1.0ml / min Detection wavelength: 240nm, 210nm

[0151] Column temperature: 30°C Injection volume: 10μl

[0152] The gradient elution procedure is the same as in Experimental Example 1.

[0153] 3 Sample preparation

[0154] Weigh the original medicinal materials of Sini Powder, decoct and extract according to the ratio in Table 19, and the extraction method is the same as...

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Abstract

This invention discloses one four inverse water boiling HPLC standard print spectrum establish method, which comprises the following steps: a, taking four inverse diffusion boiling powder and adding carbinol supersonic extracting, filtering and the filter liquid uses carbinol through micro hole filter film to get standard solution; b, extracting certain naringinase to dilute flow phase to process comparison resolution liquid; c, separately absorbing fin standard liquid and comparison liquid and adding high effective liquid phase color spectrum column to keep time and peak area value as one to compute standard relative keep time to peak proportion to get standard print spectrum.

Description

technical field [0001] The invention relates to a fingerprint of a traditional Chinese medicine composition, in particular to an HPLC standard fingerprint of Sini San water decoction and a method for establishing the same, belonging to the field of traditional Chinese medicines. Background technique [0002] Pharmacodynamic studies have found that the decoction of traditional Chinese medicine compound Sini powder has sedative and hypnotic effects, and has unique curative effects on improving sleep and improving sleep quality, but there are no reports on the material basis of its effect on improving sleep. In this study, using traditional Chinese medicine fingerprint technology and serum medicinal chemistry methods as the main research methods, the in vitro and in vivo chemical components of the Chinese medicine compound Sini powder decoction were comprehensively analyzed, and the neuroinhibitory effect was revealed through the study of the migration components in the blood. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/86G01N1/34
Inventor 都晓伟李廷利
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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