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Qingkailing Prepn for great transfusion and its prepn process

A large-scale infusion and preparation technology, which is applied in anti-inflammatory agents, medical formulas, drug delivery, etc., can solve the complex chemical composition and preparation process of Qingkailing injection, the easy problems of the clarity of small injections of traditional Chinese medicine, Qingkailing injection Eliminate problems such as easy deterioration of liquid, achieve the effects of eliminating cross-contamination, good clarity, and improving the quality of medication

Inactive Publication Date: 2007-08-22
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Qingkailing injection also has the following deficiencies in clinical application: 1. The pharmaceutical composition of Qingkailing injection contains chlorogenic acid, which is unstable under visible light, and the photosensitive surface of the small injection is highly dispersed due to the high degree of dispersion of the medicine in the small injection. increase, thus making Qingkailing injection perishable and poor in stability
2. The clarity of small injections of traditional Chinese medicine is prone to problems, and the product quality is difficult to control
3. Since Qingkailing preparations often need to be used in large doses in clinical practice, taking Qingkailing small injections to extract glucose or sodium chloride to obtain Qingkailing large infusions, the intermediate links are likely to cause cross-infection, and the safety of medication is difficult protection, but also increase the workload of medical staff
[0003] In addition, due to the complex chemical composition and preparation process of Qingkailing injection, there are often reports of adverse reactions in clinical application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Preparation of Qingkailing Glucose Infusion Preparation

[0016] (1) Add 23g of honeysuckle, 9g of Gardenia, and 75g of Radix Radix, decoct and extract twice, each time the weight of adding water is 6-8 times the weight of the medicinal material, each extraction time is 1 hour, and the extraction of each medicinal material is combined liquid, filter, and concentrate the filtrate. After concentration, the volume of the filtrate is consistent with the volume of the raw material of the medicinal material, and then add ethanol to 60% alcohol content, then refrigerate for 24 hours, then filter, recover the ethanol, and concentrate. The extracts of honeysuckle, gardenia, and Radix Radix were concentrated and subjected to HPD100, D201, and D101 macroporous resin column chromatography, and eluted with an eluent with a volume ratio of ethanol and water of 0:100 to 90:10. The eluted fractions of iridoid glycosides, geniposide and nucleosides were collected, ethanol was...

Embodiment 2

[0021] Example 2: Preparation of Qingkailing Glucose Infusion Preparation

[0022] The weight ratio of the raw material Chinese medicinal materials or their extracts used in this example is as follows: 38g of honeysuckle, 16g of Gardenia, 125g of Radix Radix, 16g of buffalo horn, 32g of mother of pearl, 3.2g of baicalin, 2.0g of cholic acid, hyodeoxycholic acid 2.4g.

[0023] Steps (1) to (4) of the preparation process of this example are the same as in Example 1; 10% glucose solution for injection to 1 L, the following steps and contents are the same as in Example 1 to prepare Qingkailing glucose large infusion preparation.

Embodiment 3

[0024] Example 3: Preparation of Qingkailing Sodium Chloride Infusion Preparation

[0025] The weight ratio of the raw material Chinese medicinal materials or their extracts used in this example is as follows: 30g of honeysuckle, 13g of gardenia, 105g of Radix Isatidis, 13g of buffalo horn, 25g of mother of pearl, 2.5g of baicalin, 1.6g of cholic acid, hyodeoxycholic acid 1.9g.

[0026]The steps (1) to (4) of the preparation process of this example are the same as those of Example 1; Sodium chloride solution for injection to 10L, the following steps and content are the same as in Example 1 to prepare Qingkailing sodium chloride large infusion preparation.

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PUM

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Abstract

The Qingkailing preparation for great transfusion is prepared with cholic acid 1.2-2.0 weight portions, hyodeoxycholic acid 1.4-2.4 weight portions, buffalo horn 9-16 weight portions, baicalin 1.8-3.2 weight portions, nacre 18-32 weight portions, prepared cape jasmine extract liquid 9-16 weight portions, prepared isatis root extract liquid 75-125 weight portions, and prepared honeysuckle extract liquid 23-38 weight portions. The present invention also discloses the preparation process of the Qingkailing preparation for great transfusion. The Qingkailing preparation for great transfusion has high clarity, high stability, high safety and other advantages.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a Qingkailingda transfusion preparation and a preparation method thereof. Background technique [0002] The series of Qingkailing preparations developed from the ancient prescription Angong Niuhuang Pills by dismantling the formula and reducing the flavor, currently have Qingkailing injection, Qingkailing powder injection, Qingkailing oral liquid, Qingkailing granules, etc. Dosage forms, Qingkailing injection in small injections is the most commonly used clinically. Qingkailing Injection has the effects of clearing away heat and detoxification, calming the nerves, and treating acute and chronic hepatitis, severe cold, high fever and other diseases. In 1995, it was listed as an essential drug by the Ministry of Health of the People's Republic of China, and was designated as one of the twenty first-aid clinical drugs at the same time. However, Qingkailing injection al...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K9/08A61P1/16A61P29/00A61K35/32A61K31/7048A61K31/575A61K35/56A61K35/618
Inventor 罗国安王义明刘清飞梁琼麟汪红英
Owner TSINGHUA UNIV
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