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Polymorphs of sarsasapogenin

A sarsasapogenin and crystallization technology, which is applied in the directions of drug combinations, pharmaceutical formulations, steroids, etc., can solve the problems of unspecified recrystallization solvents, etc., and achieves the effect of many transportation and bioavailability characteristics.

Inactive Publication Date: 2011-06-08
PHYTOPHARM LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

but does not specify the recrystallization solvent

Method used

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  • Polymorphs of sarsasapogenin
  • Polymorphs of sarsasapogenin
  • Polymorphs of sarsasapogenin

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Experimental program
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Embodiment Construction

[0045] Solvate

[0046] In principle, any organic solvent can be used to prepare the sarsasapogenin solvate and we have found that many different solvents give good results.

[0047] As mentioned previously, the solvent may contain water and one or more organic solvents.

[0048] The crystalline forms of sarsasapogenin in the prior art are not considered to be organic solvates and we conclude that the prior art does disclose the crystallization of sarsasapogenin from certain organic solvents, in particular acetone. We therefore declare that if an object in the prior art is demonstrated or found to satisfy the legal requirements for previously published sarsasapogenin ethanol solvate, sarsasapogenin acetone solvate, or any other specified solvent Saponogenin solvates or claims for such solvates under relevant legal tests, we will reserve the right to add and disclaim such solvates in the claims of this application and subsequent patents.

[0049] According to the solvate of ...

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Abstract

The invention provides sarsasapogenin in novel amorphous, crystalline, solvated and hydrated forms, and the use thereof in manufacturing pharmaceutical or edible grade sarsasapogenin and its derivatives.

Description

field of invention [0001] The present invention relates to a novel amorphous and crystalline form of sarsasapogenin and its hydrates and solvates. Background of the invention [0002] Some organic compounds may crystallize according to several polymorphic forms or crystallization habits, which may include solvates, hydrates or combinations thereof of the compounds. Alternatively, the compound, solvate or hydrate may precipitate to form an amorphous solid. [0003] The stability and bioavailability of pharmaceutical products may vary depending on the polymorphic forms present. Therefore, the choice of crystalline form is very critical for drug development (Brittain, Pharm.Tech.pp.50-52, 1994; Yu et al, Pharm, Sqi, Technol.Today, 1, pp.118 to 127, 1998; Byrn et al., Chem. Mater, 6, pp.1148 to 1158, 1994; Byrn et al., Pharm. Res., 12, pp.945 to 954, 1995; Henk et al., Pharm, Ind, 59 , pp.165 to 169, 1997) [0004] Sarsasapogenin is an A / B-cis spirostanesteroidal sapogenin w...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J71/00A61K31/58A61P3/04A61P25/28
CPCC07J71/0005A61P11/06A61P17/00A61P19/08A61P21/00A61P21/04A61P25/00A61P25/14A61P25/16A61P25/18A61P25/20A61P25/24A61P25/28A61P27/02A61P31/12A61P3/04A61P7/00A61P9/00A61P9/02A61P3/10C07J71/00A61K31/58
Inventor 彼得·大卫·蒂芬
Owner PHYTOPHARM LTD