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Composition for treating wounds and burns

A technology of composition and liquid composition, applied in the direction of drug combination, medical science, absorbent pads, etc., can solve the problems of wounds and burns that have not been disclosed successfully

Inactive Publication Date: 2007-11-14
NGEN PHARM NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there has been no publicized success in treating wounds and burns

Method used

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  • Composition for treating wounds and burns
  • Composition for treating wounds and burns

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Wound gels and wound sprays which can be used in the treatment of open wounds and burns by topical application are prepared according to the invention. The composition of the wound gel and wound spray is shown in Table 1.

[0060] Table 1

[0061] wound gel wound spray

[0062] Water 51.5% 56.5%

[0063] Component (a) 2.5% 2.5%

[0064] Component (b) 1.72% 1.72%

[0065] Component (c) 1.0% 1.0%

[0066] Wacker HDK20 5.00% 0%

[0067] (liquid adhesive)

[0068] PEG 1500 (liquid binder) 0.1% 0%

[0069] Sucrose 2.0% 2.0%

[0070] Ethanol (99.9%) 20.0% 20.0%

[0071] Glycerin 15.000% 15.000%

[0072] Cellulose gum 0.6% 0.600%

[0073] Citric acid.H 2 O 0.6% 0.63%

Embodiment 2

[0075] In this experiment, spontaneously occurring open wounds on the lateral side of the left lower extremity of diabetic patients were treated by chemical sympathectomy and by topical application of the wound gel of Example 1, following the evaluation and when deemed necessary by a skilled health professional. Personnel-adjusted dosing regimen. It is generally known that the healing process of diabetic ulcers can last up to several months with currently known treatments, and even longer without treatment. After two weeks of treatment, the wound was re-examined, and a significant improvement was observed; the surface of the wound became cleaner. Continue treatment with the wound gel of the present invention. Over the next few weeks, the appearance of the wound became cleaner and after 14 weeks of treatment with the wound gel, a significant reduction in wound diameter became observable. Wound diameter was greatly reduced when re-examined after 6 months of treatment. Continu...

Embodiment 3

[0079] Injuries to the lower extremities of patients who had become necrotic and contained hematomas could not be treated due to allergies with flammazine (Merck Index 13th Ed., p. 1586, nr. 8988 (2001)), which is currently used in the treatment of wounds such as ulcers and One of the commonly used medicines for burns. Therefore, with the wound gel treatment of Example 1, the wound was filled with the gel twice a day. After two weeks of treatment according to this protocol, follow-up examination showed a significant reduction in wound surface area and a clean normal appearance. Quantitative evaluation of wounds on Day 0 and Day 14 showed a 76% reduction in wound surface area over two weeks of treatment. It is generally known that the healing of necrotic lesions with hematomas may last up to several months when using currently common methods.

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PUM

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Abstract

The invention discloses the use of a liquid composition, capable of promoting the growth of tissue cells at the site of a wound, a process that promotes regeneration of tissue and wound healing. More particularly, the present invention relates to the use of a liquid composition comprising a component (a) selected from the salts consisting of cations An.

Description

field of invention [0001] The present invention relates to the use of a liquid composition capable of promoting the growth of tissue cells at a wound site, which is a process that promotes tissue regeneration and wound healing. More specifically, the present invention relates to the use of a liquid composition comprising cations A selected from the group consisting of n + and general formula [O m X] - Component (a) of a salt of an anion from a halogen oxide (halogen oxide), a component (b) selected from an oxygen donor, and a component (d) selected from a liquid binder. Background technique [0002] The healing process of open wounds and burns is a complex and not fully understood process. The most common means to date of treating open wounds or burns mainly consist of temporary wound closure / coverage using autografts, dermal replacement products or hydrogels such as alginates for protection from eg water loss and infection, imparting cooling and pain relieving substance...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L15/18A61L26/0076A61L26/0004A61L15/44A61L2300/412A61L2300/11A61P17/02
Inventor C·莱克拉姆W·F·范登博斯H·J·C·迈耶林克
Owner NGEN PHARM NV