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Injection containing ketoprofen and preparation method thereof

A technology for injections and organic solvents, applied in the field of ketoprofen for injection and its preparation, can solve the problems that ketoprofen has no injection form, solve the problems of solubility and administration route, slow absorption, and bioavailability high degree of effect

Inactive Publication Date: 2007-11-28
汪洪湖
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is exactly to solve the deficiency that existing ketoprofen does not have the injection form, provides a kind of injection containing ketoprofen and preparation method, and this preparation has solved product solubility and route of administration problems

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Prescription: Ketoprofen 200g

[0026] Arginine 169g

[0027] Mannitol 150g

[0028] Ethanol 500ML

[0029] Water 4500ML

[0030] Hydrochloric acid amount

[0031] Total volume 5000ML

[0032] Process: dissolving, mixing, decolorizing, filtering, subpackaging and freeze-drying the above raw and auxiliary materials.

Embodiment 2

[0034] Prescription: Ketoprofen 200g

[0035] Lysine 142g

[0036] Mannitol 200g

[0037] Ethanol 100ML

[0038] Water 9900ML

[0039] Hydrochloric acid amount

[0040] Total volume 10000ML

[0041] Process: dissolving, mixing, decolorizing, filtering, subpackaging, and freeze-drying the above raw and auxiliary materials

Embodiment 3

[0043] Prescription: Ketoprofen 200g

[0044] DL-Lysine 142g

[0045] Mannitol 200g

[0046] Ethanol 500ML

[0047] Water 5500ML

[0048] Hydrochloric acid amount

[0049] Total volume 6000ML

[0050] Process: dissolving, mixing, decolorizing, filtering, subpackaging and freeze-drying the above raw and auxiliary materials.

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Abstract

The present invention provides one kind of injection containing ketoproten and its preparation process, and features that the injection contains ketoproten, alkaline assistant and stuffing in the molar ratio between ketoproten and alkaline assistant of 1 to 1, and the weight ratio between ketoproten and stuffing of 1 to 0-10. The injection containing ketoproten is superior to traditional orally taken ketoproten preparation, and has new administration way, high product quality, high bioavailability and fast acting.

Description

Technical field: [0001] The invention relates to a medicine and a preparation method thereof, in particular to a ketoprofen for injection used for treating pain and fever caused by various causes and a preparation method thereof. Background technique [0002] Ketoprofen, which is 3-benzoyl-α-methylphenylacetic acid, is a non-steroidal anti-inflammatory drug (NSAIDs), is the first profen in the world that is clinically used and is still widely used today. It is recognized as one of the safest drugs among NSAIDs. Pharmacological action shows its anti-inflammatory, analgesic and antipyretic effects. Clinically used for various acute and chronic arthritis, soft tissue rheumatism, tenosynovitis, sports injuries and headaches, myalgia, dysmenorrhea, pain after tooth extraction, and cancer pain. The drug is recommended as the first step drug in the analgesic ladder, and it is recorded in domestic and foreign pharmacopoeias. Due to some shortcomings in pharmacodynamics and pharma...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/19A61K47/18A61P29/00
Inventor 汪洪湖
Owner 汪洪湖
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