Injection containing ketoprofen and preparation method thereof

Abstract

The present invention provides one kind of injection containing ketoproten and its preparation process, and features that the injection contains ketoproten, alkaline assistant and stuffing in the molar ratio between ketoproten and alkaline assistant of 1 to 1, and the weight ratio between ketoproten and stuffing of 1 to 0-10. The injection containing ketoproten is superior to traditional orally taken ketoproten preparation, and has new administration way, high product quality, high bioavailability and fast acting.

Description

Technical field:

[0001] The invention relates to a medicine and a preparation method thereof, in particular to a ketoprofen for injection used for treating pain and fever caused by various causes and a preparation method thereof. Background technique

[0002] Ketoprofen, which is 3-benzoyl-α-methylphenylacetic acid, is a non-steroidal anti-inflammatory drug (NSAIDs), is the first profen in the world that is clinically used and is still widely used today. It is recognized as one of the safest drugs among NSAIDs. Pharmacological action shows its anti-inflammatory, analgesic and antipyretic effects. Clinically used for various acute and chronic arthritis, soft tissue rheumatism, tenosynovitis, sports injuries and headaches, myalgia, dysmenorrhea, pain after tooth extraction, and cancer pain. The drug is recommended as the first step drug in the analgesic ladder, and it is recorded in domestic and foreign pharmacopoeias. Due to some shortcomings in pharmacodynamics and pharma...