Traditional Chinese medicinal composition containing red sage root, notoginseng, safflower and musk or muscone and its preparation

Abstract

The invention discloses a Chinese medicinal composition for treating cardiovascular diseases, which is prepared from root of red rooted saliva, notoginseng, safflower, musk or musk ketone as the raw materials, and the preparation process comprises the steps of mixing red-rooted salvia, notoginseng and safflower to obtain water extract or alcohol extract, subjecting the extract to preliminary settlement treatment, further subjecting the extract to ultrafiltration treatment, concentrating the ultrafiltrate to obtain concrete, mixing with musk or musk ketone. The invention also discloses preparations using any one of the medicinal compositions as the effective constituents, preferably drop pills.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cardiovascular diseases and a preparation thereof, in particular to a pharmaceutical composition for treating cardiovascular diseases which is made from traditional Chinese medicinal materials. Background technique [0002] With the improvement of living standards, the aging of the world's population and the rejuvenation of the disease population, cardiovascular and cerebrovascular patients are increasing year by year, and have become the second largest disease that endangers human health. Angina pectoris is a clinical syndrome caused by temporary myocardial ischemia and hypoxia, with episodic chest pain or chest discomfort as the main manifestation. Coronary heart disease angina pectoris refers to angina pectoris caused by myocardial ischemia and hypoxia due to coronary artery sclerosis or spasm, accounting for about 90% of angina pectoris patients. [0003] The current methods of tre...

AI Technical Summary

Problems solved by technology

[0008] (1) Chinese herbal medicine has complex ingredients, especially many compound preparations, the active ingredients are not fully clear, so it needs to be thoroughly researched before applying ultrafiltration technology to Chinese herbal medicine preparations. Research

For example, due to the complexity of the ingredients, it is impossible to apply ultrafiltration to the production of most traditional Chinese medicine preparations before a large number of pharmacological and clinical research tests are conducted to fully evaluate the effect of ultrafiltration on the efficacy of each ingredient in traditional Chinese medicine preparations.

[0009](2) There are few types of membrane materials, the membrane pore size distribution is wide, and the performance is not stable

Hydrophilic membrane materials such as cellulose acetate and sulfonated polysulfone have less adsorption of solutes and a smaller molecular weight cut-off, but poor thermal stability, mechanical strength, chemical resistance, and bacterial erosion resistance are usually not high; polysulfone and other hydrophobic Membrane material has high mechanical strength, high temperature resistance, solvent resistance, and biodegradation resistance, but because the molecular chain contains a large number of hydrophobic genes or chain links, and has a lot of electrostatic charges, the membrane has a low water permeability and low anti-pollution ability

[0010](3) Membrane fouling is the biggest obstacle preventing ultrafiltration technology from laboratory research to industrial application

In the ultrafiltration process of traditional Chinese medicine preparations, if the pretreatment effect of the liquid medicine is not good, the membrane surface will be easily polluted and the membrane pores will be blocked, which will reduce the permeation flux, that is, the productivity, or even fail to work normally, reduce the production efficiency, and increase the cost, resulting in membrane shortened service life

[0011](4) The selection method of membrane modules has not yet been established, and the ultrafiltration operating parameters still need to be optimized

However, due to the strict requirements of the drop pill preparation process on the matrix excipients, it is often difficult to prepare drop pills that meet the quality requirements after replacing the matrix excipients. Therefore, finding a suitable matrix excipient to replace the current polyethylene glycol has become a constant effort of medical personnel. direction