Compound red sage root preparation for treating cardiovascular diseases and its preparation technology

A compound preparation and cardiovascular technology, which can be used in cardiovascular system diseases, medical preparations containing active ingredients, pill delivery, etc., and can solve the problems of large toxic side effects and many adverse reactions

Inactive Publication Date: 2007-12-12
朱志宏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The western medicines currently on the market for the treatment of cardiovascular and cerebrovascular diseases have relatively large toxic and side effects and many adverse reactions, such as cilostazol, etc

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Weigh 5g of salvianolic acid and 10g of breviscapine respectively, add auxiliary materials such as starch, microcrystalline cellulose, sodium lauryl sulfate, sucrose, etc., mix evenly, granulate, granulate, dry, compress into tablets, and prepare into tablets 1000 pieces.

Embodiment 2

[0020] Take by weighing salvianolic acid 3g and breviscapine 300g respectively, prepare into capsules according to the following method:

[0021] A. Weigh the breviscapus in proportion, add 10 times of water to decoct 3 times, 0.5h each time, concentrate the decoction to a relative density of 1.10 (50°C), add ethanol to make the alcohol content 55%, stir, and place , filtered, and the filtrate recovered ethanol under reduced pressure to a relative density of 1.10 (50°C), adjusted the pH value to 2 with hydrochloric acid, kept at 55°C for 6 hours, filtered, recrystallized, and dried in vacuo.

[0022] B. Pulverize the scutellarin obtained in A, grind it into powder, mix it with the salvianolic acid weighed in proportion, add the corresponding auxiliary materials pregelatinized starch, Tween-80, magnesium stearate, and hydroxymethyl cellulose Etc., granulating, sizing, mixing, drying, and filling into ordinary gelatin capsules. Prepare 1000 capsules.

Embodiment 3

[0024] Weigh 2g of danshensu and 50g of breviscapine, extract breviscapine according to the method in Example 2 to obtain breviscapine, grind and mix danshensu and breviscapine evenly, add 15ml of water for injection to dissolve, add 0.8g Shake well to dissolve the medicinal sodium chloride, add an appropriate amount of benzyl alcohol, sodium sulfite, etc., add an appropriate amount of sodium hydroxide to adjust the pH of the solution between 4.5 and 5.0, add water to 1000ml, stir well, filter and divide into 5ml Sterilize with circulating steam at 100°C for 45 minutes in a permanent glass container.

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PUM

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Abstract

The invention provides a Chinese medicinal compound preparation for treating cardiovascular diseases characterized in that, the preparation comprises one of salvia miltiorrhizae or its effective constituent of salvianolic acid, one of Erigeron breviscapus or its effective constituent of Breviscapine, and pharmaceutically acceptable auxiliary materials. The invention also provides a process for preparing the Chinese medicinal composition for treating cardiovascular diseases.

Description

field of invention [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a medicine for treating cardiovascular diseases and a production process thereof, in particular to a traditional Chinese medicine salvia miltiorrhiza or its effective component salvianolic acid and breviscapine or its effective component breviscapine. A drug composed of two main ingredients and suitable medicinal excipients, used for stroke caused by blood stasis in Yin collaterals, sequelae caused by cerebrovascular accident, paralysis and rheumatic pain, coronary heart disease, myocardial infarction , angina pectoris and other cardiovascular and cerebrovascular diseases. Background technique [0002] According to national statistics, the number of hypertensive patients in my country has reached 100 million, and more than 3 million people are newly added every year. There are more than 5 million stroke patients, 1.5 million new cases and 200,000 deaths every year; i...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/16A61K9/20A61K9/48A61P9/10
Inventor 朱志宏
Owner 朱志宏
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