Compound red sage root preparation for treating cardiovascular diseases and its preparation technology
A compound preparation and cardiovascular technology, which can be used in cardiovascular system diseases, medical preparations containing active ingredients, pill delivery, etc., and can solve the problems of large toxic side effects and many adverse reactions
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Embodiment 1
[0018] Weigh 5g of salvianolic acid and 10g of breviscapine respectively, add auxiliary materials such as starch, microcrystalline cellulose, sodium lauryl sulfate, sucrose, etc., mix evenly, granulate, granulate, dry, compress into tablets, and prepare into tablets 1000 pieces.
Embodiment 2
[0020] Take by weighing salvianolic acid 3g and breviscapine 300g respectively, prepare into capsules according to the following method:
[0021] A. Weigh the breviscapus in proportion, add 10 times of water to decoct 3 times, 0.5h each time, concentrate the decoction to a relative density of 1.10 (50°C), add ethanol to make the alcohol content 55%, stir, and place , filtered, and the filtrate recovered ethanol under reduced pressure to a relative density of 1.10 (50°C), adjusted the pH value to 2 with hydrochloric acid, kept at 55°C for 6 hours, filtered, recrystallized, and dried in vacuo.
[0022] B. Pulverize the scutellarin obtained in A, grind it into powder, mix it with the salvianolic acid weighed in proportion, add the corresponding auxiliary materials pregelatinized starch, Tween-80, magnesium stearate, and hydroxymethyl cellulose Etc., granulating, sizing, mixing, drying, and filling into ordinary gelatin capsules. Prepare 1000 capsules.
Embodiment 3
[0024] Weigh 2g of danshensu and 50g of breviscapine, extract breviscapine according to the method in Example 2 to obtain breviscapine, grind and mix danshensu and breviscapine evenly, add 15ml of water for injection to dissolve, add 0.8g Shake well to dissolve the medicinal sodium chloride, add an appropriate amount of benzyl alcohol, sodium sulfite, etc., add an appropriate amount of sodium hydroxide to adjust the pH of the solution between 4.5 and 5.0, add water to 1000ml, stir well, filter and divide into 5ml Sterilize with circulating steam at 100°C for 45 minutes in a permanent glass container.
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