Di'ao Xinxuekang sustained-release preparation and its preparation method and use

A slow-release preparation and heart blood technology, which is applied in pharmaceutical formulations and drug delivery, can solve the problems of unsuitable sustained-release preparations and unseen reports on the preparation process of Diaoxinxuekang sustained-release preparations, so as to reduce the frequency of medication, improve curative effect, Reduce the effect of blood concentration peak and valley

Active Publication Date: 2011-12-28
CHENGDU DIAO PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, since the steroidal total saponins from the yellow yam or / and Dioscorea punctatus rhizome are almost insoluble in water ("Chinese Pharmacopoeia" 2005, 430), the drugs with poor water solubility are generally not suitable for the preparation of sustained-release preparations ("Pharmaceuticals" The fifth edition, People's Health Publishing House, edited by Cui Fude, 397, 400), will not select drugs with poor solubility when designing sustained-release preparations, so it is difficult to prepare Di'ao Xinxuekang into a sustained-release preparation suitable for clinical use by conventional methods. In the prior art, there is no report on the study of Di'ao Xinxuekang sustained-release preparation and its preparation process.

Method used

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  • Di'ao Xinxuekang sustained-release preparation and its preparation method and use
  • Di'ao Xinxuekang sustained-release preparation and its preparation method and use
  • Di'ao Xinxuekang sustained-release preparation and its preparation method and use

Examples

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Comparison scheme
Effect test

Embodiment 1

[0036] [Example 1] Preparation of sustained-release tablet of the present invention

[0037] 1. Preparation of solid dispersion of traditional Chinese medicine yellow yam or diosminum diosminum total saponins

[0038] (1) Prescription of traditional Chinese medicine yellow yam or yam yam solid dispersion:

[0039] The total saponins of traditional Chinese medicine Huang Yam or Dioscorea punctatus are limited to 50mg

[0040] Polyethylene glycol 150mg

[0041] (2) The preparation process of the solid dispersion of the traditional Chinese medicine Huang Yam or Dioscorea diosminum saponins:

[0042] According to the above prescription, weigh the traditional Chinese medicine yellow yam or total saponins of Dioscorea chinensis, add an appropriate amount of absolute ethanol, put it in a water bath at 75°C, stir until it is completely dissolved, then slowly add polyethylene glycol, and stir until it is completely dissolved , When the solvent is evaporated to viscous, it is suddenl...

Embodiment 2

[0051] [Example 2] Preparation of sustained-release tablet of the present invention

[0052] 1. Preparation of solid dispersion of traditional Chinese medicine yellow yam or diosminum diosminum total saponins

[0053] (1) Prescription of traditional Chinese medicine yellow yam or yam yam solid dispersion:

[0054] Chinese medicine yellow yam or total saponins of Dioscorea punctatus 50mg

[0055] Polyethylene glycol 150mg

[0056] (2) The preparation process of the solid dispersion of the traditional Chinese medicine Huang Yam or Dioscorea diosminum saponins:

[0057] According to the above prescription, weigh the traditional Chinese medicine yellow yam or total saponins of Dioscorea chinensis, add an appropriate amount of absolute ethanol, put it in a water bath at 75°C, stir until it is completely dissolved, then slowly add polyethylene glycol, and stir until it is completely dissolved , When the solvent is evaporated to viscous, it is suddenly frozen and solidified. Dry ...

Embodiment 3

[0069] [Example 3] Preparation of sustained-release tablet of the present invention

[0070] 1. Preparation of solid dispersion of traditional Chinese medicine yellow yam or diosminum diosminum total saponins

[0071] (1) Prescription of traditional Chinese medicine yellow yam or yam extract solid dispersion:

[0072] Traditional Chinese Medicine Yellow Yam or Dioscorea chinensis Total Saponins 300mg

[0073] Polyvinylpyrrolidone 220mg

[0074] Sodium Lauryl Sulfate 25mg

[0075] (2) The preparation process of the solid dispersion of the traditional Chinese medicine Huang Yam or Dioscorea diosminum saponins:

[0076] According to the above prescription, weigh the traditional Chinese medicine yellow yam or total saponins of Dioscorea chinensis and sodium lauryl sulfate, add an appropriate amount of absolute ethanol, place in a water bath at 75°C, stir until it is completely dissolved, then slowly add polyvinylpyrrolidone, After stirring to make it completely dissolved, when...

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Abstract

The invention provides a Di'ao Xinxuekang sustained-release preparation, which is composed of steroidal total saponins extracted from the rhizome of Chinese yam or/and Dioscorea punctatus as active ingredients, combined with solid dispersion technology and melting granulation technology or slow-release coating technology , that is, firstly mix the total steroidal saponins with a hydrophilic carrier material or/and a solubilizer to prepare a solid dispersion with excellent solubility, and then add a slow-release material to prepare the preparation. In vitro tests show that the sustained-release preparation is released continuously and smoothly within 24 hours, which provides a new option for the prevention and treatment of cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to a slow-release preparation of traditional Chinese medicine, in particular to a slow-release preparation of Di'ao Xinxuekang and its preparation method and application. Background technique [0002] Coronary heart disease and angina pectoris refer to the clinical syndrome caused by insufficient coronary blood supply, myocardial ischemia and hypoxia. "Heartache" and other syndrome categories. According to traditional Chinese medicine, the syndrome of thoracic obstruction is always a syndrome of deficiency in origin and excess in superficiality. Paralyzed. The cause of blocked heart vessels is of course due to blood stasis, phlegm turbidity, and stagnation of qi, and the occurrence of stasis, phlegm, and stagnation of qi is the result of long-term dysfunction of the viscera. Loss-based. Cardiac blockage, blockage leads to pain, chest pain attack or discomfort in the heart and chest; blood stasis blocks the collaterals, and the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22
Inventor 叶兵鲍锐李伯刚黄瑜刘忠荣及元乔黄沛
Owner CHENGDU DIAO PHARMA GROUP
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