Method of preparing newcastle disease, infectiousness bronchitis bigeminy killed vaccine

A dual inactivated vaccine and bronchitis technology, which is applied in the field of preparation of chicken Newcastle disease and infectious bronchitis dual inactivated vaccine, can solve problems such as infectious diseases affecting the respiratory tract of chickens in the poultry industry, and reduce the stress of inoculated animals. The number of reactions, the amount of saving, and the effect of improving efficiency

Inactive Publication Date: 2008-01-23
PU LIKE BIO ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the problem that Newcastle disease and infectious bronchitis seriously affect the poultry industry, especially the respiratory infectious diseases of chickens, the purpose of this invention is to provide a preparation...

Method used

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Effect test

specific Embodiment approach 2

[0023] Preparation of virus seeds for production: NDV La Sota strain and IBV M 41 Strain viruses were diluted appropriately, respectively inoculated with SPF chicken embryos, hatched, and harvested males; preparation of virus liquid for making seedlings: NDV La Sota strain and IBV M 41 Strain viruses were diluted appropriately, respectively inoculated with susceptible chicken embryos, and incubated; harvested live virus seeds, respectively concentrated, inactivated, and used NDV La Sota virus strain 16% and IBV M for making seedlings. 41 Virus strain liquid 16%, add Tween-802%, make water phase, make oil phase with white oil 60%, Siben-804%, aluminum stearate 2%, the ratio of water phase and oil phase is 1 : 2 are emulsified together, packaged, labeled, boxed, and stored.

specific Embodiment approach 3

[0024] Preparation of virus seeds for production: NDV La Sota strain and IBV M 41 Strain viruses were diluted appropriately, inoculated with SPF chicken embryos, incubated, and harvested; preparation of virus liquid for seedlings: NDV La Sota strain and IBV M 41 Strain viruses were diluted appropriately, respectively inoculated with susceptible chicken embryos, and incubated; the live virus seeds were collected, respectively concentrated, inactivated, and NDV La Sota virus strain 17% and IBV M were used for seedling preparation. 41 The water phase was made by adding Tween-802% to 17% of the virus strain liquid. The oil phase was made from 60% white oil, 2% Siben-804%, and 2% aluminum stearate, and the ratio of the water phase to the oil phase was 1:2.5 Emulsify together; pack, label, pack, store.

specific Embodiment approach 4

[0025] Preparation of virus seeds for production: NDV La Sota strain and IBV M 41 Strain virus seeds were diluted appropriately, and SPF chicken embryos were inoculated at the same time, incubated and harvested; preparation of virus liquid for seedlings: NDV La Sota strain and IBV M 41 The virus seeds of the strain were diluted appropriately, and at the same time inoculated susceptible chicken embryos, and incubated; the virus seeds were harvested, inactivated, and Tween-802% was added to make a water phase, and white oil 60%, Siben-804%, aluminum stearate 2% is made into an oil phase, and the ratio of the water phase to the oil phase is 1:2 and emulsified together; subpackaged, labeled, packed, and put into storage.

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Abstract

The invention relates to a method to prepare a combined inactive vaccine of newcastle disease and infectious bronchitis vaccine for chicks. The invention is characterized in that: firstly, concentrate and inactivate the NDVLaSota virus strains (10 per cent to 22 per cent weight ratio) and IBVM41 virus strains (10 per cent to 22 per cent weight ratio) respectively; and then add white oil and immune additives including tween, span and stearic acid to prepare the combined vaccine.

Description

Technical field: [0001] The invention relates to a biological agent for poultry, which is a preparation method of a dual inactivated vaccine of Newcastle disease and infectious bronchitis. Background technique: [0002] Prevention and control of infectious diseases is of great significance to the modern poultry industry. At present, the commonly used methods are mainly to strengthen sanitation and disinfection, but these alone cannot make the intensive large-scale production of the modern poultry industry resist the spread of infectious diseases, and it is common to cause great losses to the poultry industry. Facts have proved that the most important means of controlling infectious diseases in the poultry industry should be prevention, and vaccination is considered to be the most effective measure. [0003] Vaccines are autoimmune preparations made from pathogenic microorganisms (such as bacteria, rickettsia, viruses, etc.) and their metabolites, which are artificially atte...

Claims

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Application Information

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IPC IPC(8): A61K39/215A61K39/12A61P11/00
Inventor 张许科孙进忠乔荣岑荣骏弓习向峰
Owner PU LIKE BIO ENG
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