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Application of typhoid fever and paratyphoid fever salmonella in the aspect of fast anti-tumor

A paratyphoid and salmonella technology, which can be used in anti-tumor drugs, resistance to vector-borne diseases, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2008-01-30
罗舒仓
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although surgery can remove the primary focus, it cannot fundamentally eliminate the regeneration and reproduction of tumor cells, which is the root cause of tumor recurrence and metastasis in the future. Although radiotherapy and chemotherapy can kill cancer cells, it also makes a large number of normal cells Severe damage to tissue cells can induce gastrointestinal reactions, bone marrow suppression, and liver, kidney, and heart dysfunction, causing severe failure of various organs in the body, making it difficult to accept further treatment, and eventually leading to the death of the patient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0008] The present invention proposes the application of typhoid and paratyphoid Salmonella in rapid anti-tumor, and further explanation will be given below with several representative types of tumors as experimental examples.

[0009] Experiment 1 Application of Salmonella typhi in anti-liver cancer

[0010] Experimental material: injection of Salmonella typhi: typhoid (50071)

[0011] Experimental method: select 32 Kunming mice, female, 20g±2, inoculate H22, liver cancer cells 1×10 6 / only, under the skin of the right armpit. The next day, they were randomly divided into 4 groups: control group, low-dose group (1250U / monkey / time), medium-dose group (2500U / bird / time), and high-dose group (5000U / bird / time), with 8 animals in each group , Calculate the survival days of mice in each group.

[0012] Experimental results:

[0013] serial number

group

average survival time

1

control group

15±3 days

2

Low dose group (1250U / piece / time) ...

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PUM

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Abstract

The present invention discloses an application of typhoid and paratyphoid salmonella in the anti-tumor aspect, which is invented to solve the problems of great side effects and poor effects of the prior art in the treatment of tumors. The present invention provides the application of the typhoid and paratyphoid salmonella in the rapid anti-tumor aspect. Wherein, the tumors are one or more of gastric cancer, lung cancer, liver cancer, tongue squamous cancer, breast cancer, colon cancer, leukemia, brain tumor and sarcoma. The invention makes use of the rapid combination of the typhoid and paratyphoid salmonella with the mononuclear cells after entering into the human body, the strong endotoxin and bacteremia are released and the temperature reaches highly around 40 DEG C to 42 DEG C, so as to affect and inhibit the growth and the life cycle of the tumor cells, furthermore, the large mononuclear cells-macrophages in the reticuloendothelial system are proliferated greatly, thus enhancing the ability of the macrophages in vivo to swallow the cancer cells, so the invention has very significant inhibiting and killing effects of a variety of tumors.

Description

technical field [0001] The invention relates to the application of typhoid and paratyphoid Salmonella in rapid anti-tumor. Background technique [0002] Malignant tumors (cancers) are a class of diseases that seriously threaten human life and health. According to the latest statistical data, there are about 1.6 million new cancer patients in my country every year, and about 1.3 million deaths. In the world, cancer kills about 6 million people every year, and puts 10 million people on the verge of death. The incidence of tumors is increasing year by year. The World Health Organization predicts that cancer will become the "first killer" of human death in the 21st century. The current modern medical treatment of tumors is mainly surgical treatment combined with radiotherapy and chemotherapy. Although surgery can remove the primary focus, it cannot fundamentally eliminate the regeneration and reproduction of tumor cells, which is the root cause of tumor recurrence and metastas...

Claims

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Application Information

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IPC IPC(8): A61K35/74A61P35/00A61K39/00
CPCA61K2039/522A61K2039/523A61K39/0011A61K35/74A61P35/00A61P35/02Y02A50/30
Inventor 罗舒仓
Owner 罗舒仓
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