Compound amino acid injection composition suitable for kidney disease patient

A compound amino acid and composition technology, which is applied in the direction of drug combination, active ingredients of anhydride/acid/halide, pharmaceutical formula, etc., can solve the problems of low, neglected, and unreasonable content of essential amino acids, and achieve the purpose of improving nutritional status and correcting negative Nitrogen balance, the effect of correcting amino acid imbalance state

Active Publication Date: 2008-02-13
费森尤斯卡比华瑞制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] From the perspective of prescription composition, the prescription design of Compound Amino Acid Injection (9AA) is reasonable but also unreasonable
The rationality is reflected in the fact that the

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0063] Example one:

[0064] Weigh each amino acid raw material according to the following table:

[0065] Ingredient content

[0066] L-Isoleucine 4.08g

[0067] L-Leucine 8.24g

[0068] L-Lysine Acetate 8.008g

[0069] L-methionine 2.24g

[0070] Acetylcysteine ​​0.4 g

[0071] L-phenylalanine 3.04g

[0072] L-threonine 3.84g

[0073] L-tryptophan 1.52g

[0074] L-valine 4.96g

[0075] L-arginine 3.92g

[0076] L-histidine 3.44g

[0077] Glycine 2.56g

[0078] L-Alanine 5.04g

[0079] L-Proline 3.44g

[0080] L-serine 3.6 g

[0081] L-malic acid 1.2 g

[0082] Rinse all production equipment with water for injection, and protect the product with nitrogen filtered through 0.22μm pore size during the entire production process.

[0083] Put the weighed amino acid raw materials into the preparation tank. The preparation tank is evacuated to a vacuum degree of more than 80%, and nitrogen is filled to a positive pressure after evacuating.

[0084] Under the protection of nitrogen, add ...

Example Embodiment

[0090] Embodiment two:

[0091] Weigh each amino acid raw material according to the following table:

[0092] Ingredient weight

[0093] L-Isoleucine 5.10g

[0094] L-leucine 10.30 g

[0095] L-lysine acetate 10.01 g

[0096] L-methionine 2.80g

[0097] Acetylcysteine ​​0.50 g

[0098] L-phenylalanine 3.80 g

[0099] L-threonine 4.80g

[0100] L-tryptophan 1.90g

[0101] L-valine 6.20g

[0102] L-arginine 4.90g

[0103] L-histidine 4.30g

[0104] Glycine 3.20g

[0105] L-alanine 6.30 g

[0106] L-Proline 4.30g

[0107] L-serine 4.50 g

[0108] L-malic acid 1.50 g

[0109] Rinse all production equipment with water for injection, and protect the product with nitrogen filtered through 0.22μm pore size during the entire production process.

[0110] Put the weighed amino acid raw materials into the preparation tank. The preparation tank is evacuated to a vacuum degree of more than 80%, and nitrogen is filled to a positive pressure after evacuating.

[0111] Under the protection of nitr...

Example Embodiment

[0117] Embodiment three:

[0118] Weigh each amino acid raw material according to the following table:

[0119] Ingredient weight

[0120] L-Isoleucine 6.12g

[0121] L-Leucine 12.36g

[0122] L-Lysine Acetate 12.012g

[0123] L-methionine 3.36g

[0124] Acetylcysteine ​​0.6 g

[0125] L-phenylalanine 4.56 g

[0126] L-threonine 5.76 g

[0127] L-tryptophan 2.28g

[0128] L-valine 7.44g

[0129] L-Arginine 5.88g

[0130] L-histidine 5.16 g

[0131] Glycine 3.84g

[0132] L-Alanine 7.56g

[0133] L-Proline 5.16g

[0134] L-serine 5.4 g

[0135] L-malic acid 1.8 g

[0136] Rinse all production equipment with water for injection, and protect the product with nitrogen filtered through 0.22μm pore size during the entire production process.

[0137] Put the weighed amino acid raw materials into the preparation tank. The preparation tank is evacuated to a vacuum degree of more than 80%, and nitrogen is filled to a positive pressure after evacuating.

[0138] Under the protection of nitrog...

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PUM

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Abstract

The invention relates to a compound amino acid injection composition and a preparation method thereof. The injection is characterized in that: besides the essential amino acids for human body, the prescription also contains non-essential amino acids that cannot be synthesized in the body or are insufficiently synthesized in the condition of kidney disease. The preparation of the compound amino acid injection under the condition of strictly controlling the aerobic environment can make the product meet the quality requirements without any antioxidant. This product is suitable for patients with kidney disease and meets their special requirements for various essential and non-essential amino acids. It not only balances the amino acid content in the patient's body, but also supplements nutrition; no antioxidants are added to the prescription, which can effectively reduce the occurrence of adverse reactions in clinical application Rate.

Description

technical field [0001] The invention discloses a compound amino acid injection composition containing 15 kinds of amino acids and a preparation method thereof. The prescription of the compound amino acid injection composition is suitable for kidney disease patients. Background technique [0002] Acute renal failure is a clinical syndrome characterized by a sharp decrease in renal excretory function and a serious disorder in the internal environment of the body caused by various reasons. In acute renal failure, the body is in a state of stress, and catabolism is greater than anabolism. Kidney function drops sharply, and toxins accumulate in the body, causing symptoms of poisoning in various systems throughout the body. Among them, gastrointestinal symptoms appear first, such as loss of appetite, nausea, vomiting, diarrhea, etc., which reduce the daily intake of nutrients and stimulate the body to consume its own reserves and use protein and fat for energy. Acute renal failu...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/198A61K31/19A61K31/401A61K31/405A61K31/4172A61P13/12
Inventor 马涛
Owner 费森尤斯卡比华瑞制药有限公司
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