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Medicinal composition containing injection cefmenoxime hydrochloride and compound amino acid injection

A technology of cefmenoxime hydrochloride and compound amino acids, which is applied in the fields of drug combination, antibacterial drug, and pharmaceutical formula

Inactive Publication Date: 2014-04-16
海南路易丹尼生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In addition, the prior art only mentions in the instructions for use that cefmenoxime hydrochloride for injection can be dissolved in 0.9% sodium chloride injection or glucose injection for intravenous infusion. Adults can also take the dose of this product once Add 0.5g-2g to the rehydration fluid such as sugar solution, electrolyte solution or amino acid preparation, and infuse intravenously within 30 minutes to 2 hours
However, in clinical use, it is necessary to purchase joint applications separately, and there is no combination package of cefmenoxime hydrochloride for injection and compound amino acid injection on the market or in medical institutions.

Method used

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  • Medicinal composition containing injection cefmenoxime hydrochloride and compound amino acid injection
  • Medicinal composition containing injection cefmenoxime hydrochloride and compound amino acid injection
  • Medicinal composition containing injection cefmenoxime hydrochloride and compound amino acid injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Preparation of Cefmenoxime Hydrochloride for Injection

[0030] prescription:

[0031]

[0032] making process:

[0033] (1) 250g of sterile cefmenoxime hydrochloride powder (in C 16 h 17 N 9 o 5 S 3 ) 2 HC1 meter) sent to the subpackaging room (the ambient temperature of the subpackaging post is 18℃~26℃, and the relative humidity is below 65%), debug the subpackaging machine, adjust the number of steps to adjust the loading volume, so that the loading volume reaches the specified range, Then it is divided into injection bottles with low borosilicate glass tubes, the stoppers are fully pressed, and the caps are capped.

[0034] (2) Cefmenoxime hydrochloride sterile powder 500g (in C 16 h 17 N 9 o 5 S 3 ) 2 HC1 meter) sent to the subpackaging room (the ambient temperature of the subpackaging post is 18℃~26℃, and the relative humidity is below 65%), debug the subpackaging machine, adjust the number of steps to adjust the loading volume, so that ...

Embodiment 2

[0037] Example 2 Preparation of Compound Amino Acid Injection

[0038] prescription:

[0039]

[0040] making process:

[0041] (1) Take 60L of water for injection and boil it, add 5000g of xylitol to dissolve it, then add 150g of activated carbon and boil for 20 minutes, filter back to decolorize for 20 minutes, then filter into dilute irrigation.

[0042] (2) After filtering the xylitol liquid into the dilution tank, nitrogen gas is introduced immediately, and at the same time, another 40 L of water for injection that has been pretreated with 150 g of activated carbon for 20 minutes of boiling and adsorption is combined with the xylitol liquid, and the cooling water is used When the combined solution was cooled to 60°C, feeding began.

[0043] (3) Divide 50g of the antioxidant sodium bisulfite into two equal parts, put 25g of one part of the antioxidant into the combined liquid, then add 289g of arginine hydrochloride and 246g of histidine hydrochloride according to t...

Embodiment 3

[0046] Example 3 Preparation of Combination Packaged Drugs

[0047] Combination 1: Cefmenoxime hydrochloride for injection 0.25g and compound amino acid injection 100ml.

[0048] Combination 2: Cefmenoxime hydrochloride for injection 0.25g and compound amino acid injection 250ml.

[0049] Combination 3: 0.25g of cefmenoxime hydrochloride for injection and 500ml of compound amino acid injection.

[0050] Combination 4: Cefmenoxime hydrochloride for injection 0.5g and compound amino acid injection 100ml.

[0051] Combination 5: Cefmenoxime hydrochloride for injection 0.5g and compound amino acid injection 250ml.

[0052] Combination 6: Cefmenoxime hydrochloride for injection 0.5g and compound amino acid injection 500ml.

[0053] Combination 7: 1.0 g of cefmenoxime hydrochloride for injection and 100 ml of compound amino acid injection.

[0054] Combination 8: 1.0 g of cefmenoxime hydrochloride for injection and 250 ml of compound amino acid injection.

[0055] Combination...

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PUM

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Abstract

The invention relates to a medicinal composition containing injection cefmenoxime hydrochloride and a compound amino acid injection, and especially relates to a medicinal composition packaged in a combination manner and comprising injection cefmenoxime hydrochloride and the compound amino acid injection. When the medicinal composition is used, the injection cefmenoxime hydrochloride is added to the compound amino acid injection, and the medicinal composition is intravenously dripped for 30min-2h. Compared with a compatible mixture of the injection cefmenoxime hydrochloride and the compound amino acid injection, the combination packaged medicinal composition allows the steps to be simplifies, the safety to be improved, the stability of cefmenoxime hydrochloride to be large and the clinical application quality and the bioavailability of the medicinal composition to be improved.

Description

technical field [0001] The invention relates to a pharmaceutical composition of cefmenoxime hydrochloride for injection and compound amino acid injection, in particular to a combination of cefmenoxime hydrochloride for injection, sterilized injection prepared from 18 kinds of crystalline amino acids and xylitol The application packaging belongs to the technical field of medicine. Background technique [0002] Cefmenoxime hydrochloride is a third-generation semi-synthetic broad-spectrum cephalosporin antibiotic, which achieves bactericidal effect by inhibiting the biosynthesis of bacterial cell walls. The strong antibacterial effect of cefmenoxime hydrochloride on Gram-negative bacteria is due to its good outer membrane permeability, stability to β-lactamase, and inhibition of penicillin-binding proteins (PBPs) 1A, 1B and 3 Strong affinity, so it has a strong hindering effect on the formation of cell wall mucopeptide crosslinks. [0003] In vitro tests have shown that the p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/546A61K31/4172A61K31/405A61K31/401A61K31/198A61K31/195A61K47/10A61P31/04A61P3/02
Inventor 祝云琴
Owner 海南路易丹尼生物科技有限公司
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