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Method for producing medicament for treating headache

A production method and drug technology, applied in the field of production of drugs for the treatment of headaches, can solve problems such as clinical requirements are far apart, and achieve the effects of improving hemorheology, reducing whole blood viscosity, and better curative effect

Active Publication Date: 2008-02-27
JUMPCAN PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Medical scientists at home and abroad have done a lot of work and made great progress in the research on the pathogenesis of headache and effective drugs, but the problem has not been solved, and it is far from the clinical requirements.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 140.0 grams of Scutellaria baicalensis, 92.5 grams of Chuanxiong, 92.5 grams of Angelica, 92.5 grams of Fangfeng, 92.5 grams of Angelica, 92.5 grams of Ophiopogon japonicus, 92.5 grams of Notopterygium, 92.5 grams of Duhuo, 92.5 grams of Cangzhu, 47.5 grams of Chrysanthemum, 47.5 grams of Vitex, 27.5 grams of Asarum grams, licorice 27.5 grams, ginger 13.8 grams. in:

[0025] (1) Take Chuanxiong, Angelica, Fangfeng, Angelica dahurica, Asarum, Notopterygium, Duhuo, Atractylodes, Chrysanthemum and Vitex by steam distillation to extract the volatile oil; make the obtained volatile oil into β-cyclodextrin inclusion things.

[0026] The inclusion method of β-cyclodextrin of volatile oil: Take 1ml of volatile oil, dissolve it in 4ml of ethanol, take another 5 grams of β-cyclodextrin, add 125ml of water, dissolve at 55°C under heat preservation and stirring, and dissolve the above-mentioned The volatile oil solution is slowly added dropwise to the β-cyclodextrin solution. Aft...

Embodiment 2

[0031] 140.0 grams of Scutellaria baicalensis, 92.5 grams of Chuanxiong, 92.5 grams of Angelica, 92.5 grams of Fangfeng, 92.5 grams of Angelica, 92.5 grams of Ophiopogon japonicus, 92.5 grams of Notopterygium, 92.5 grams of Duhuo, 92.5 grams of Cangzhu, 47.5 grams of Chrysanthemum, 47.5 grams of Vitex, 27.5 grams of Asarum grams, licorice 27.5 grams, ginger 13.8 grams. in:

[0032] (1) Take Chuanxiong, Angelica, Fangfeng, Angelica dahurica, Asarum, Notopterygium, Duhuo, Atractylodes, Chrysanthemum and Vitex by steam distillation to extract the volatile oil; make the obtained volatile oil into β-cyclodextrin inclusion things.

[0033] The β-cyclodextrin inclusion method of volatile oil: take 1ml of volatile oil, dissolve it in 3-5ml ethanol, take another 4-6 grams of β-cyclodextrin, add 100-150ml of water, and dissolve it at 40-60℃ with stirring , slowly add the above-mentioned volatile oil solution into the β-cyclodextrin solution dropwise under heat preservation and stirring....

Embodiment 3

[0038] Example 3: Effects on Pain Response of Mice Caused by Intraperitoneal Stimulation of Acetic Acid

[0039] Take 60 normal ICR mice, weighing 18-22 g, half male and half male. Divided into 4 groups at random, every group of 20 mice, (1) model group: give distilled water 20ml / kg; (2) group of medicine (embodiment 1) of the present invention: give 4g / kg and 2g / kg respectively; (3 ) decoction group: take each main ingredient according to the prescription, decoct it with water, combine the decoction liquid and concentrate it appropriately (the same below). Give 4g / kg. Mice in each group were administered intragastrically at 20 ml / kg body weight, once a day for 3 consecutive days. After 40 minutes of administration on the third day, mice in each group were intraperitoneally injected with 0.6% acetic acid 0.2ml / only, and the number of animals and times of writhing reactions in mice in each group were observed within 15 minutes after the injection of acetic acid. The results ...

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Abstract

The invention relates to a medicament for treating cephalalgia, especially vascular nerve cephalalgia and process for preparation. Compared with directly grilled medicinal broth, the medicament provided by the present invention is capable of improving product stability and application conformability through reasonable combination of variious techniques, and the effective compositions can be fully extracted.

Description

technical field [0001] The invention relates to a medicine for treating headache and a production method thereof. The medicine contains the following raw materials in parts by weight: 56 parts of Scutellaria baicalensis, 37 parts of Rhizoma Chuanxiong, 37 parts of Angelica sinensis, 37 parts of Fangfeng, 37 parts of Angelica dahurica, 37 parts of Radix Ophiopogon japonicus, 37 parts of Notopterygium, 37 parts of Duhuo, 37 parts of Cangzhu, 19 parts of Chrysanthemum, 19 parts of Vitex, 11 parts of Asarum, 11 parts of Licorice, and 4-7 parts of Ginger. The drug has the effect of treating headache, especially angioneurotic headache. It belongs to the field of medicine. Background technique [0002] Headache is one of the most common clinical symptoms, which can be found in various acute and chronic diseases. Various types of headaches have become the main interest of neuroscientists at home and abroad in recent years. Medical scientists at home and abroad have done a lot of ...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/16A61K47/40A61P25/04
Inventor 曹龙祥李昌龙田刚
Owner JUMPCAN PHARMA GRP
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