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Classifying image features

A technology of images and image piles, applied in the directions of instruments, computing, character and pattern recognition, etc.

Active Publication Date: 2008-03-26
CAMBRIDGE RES & INSTR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In fact, either because the multiple colorations are in fact confined to common structures in the sample, or because due to the preparation method, a structure containing one coloration within the sample overlaps a second structure containing a different coloration, can lead to the observed overlapping

Method used

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Embodiment Construction

[0036] overview

[0037] The methods and systems disclosed herein can be used to classify a wide variety of biological or other samples based on spectral and / or structural features present on images of the samples. The classification method includes at least some steps performed in an automated fashion using machine vision algorithms and techniques. A collection of images of samples is obtained and may be transformed before being submitted to an automatic classifier. Transformation of image sets may include mathematical transformations, such as conversion from intensity to optical density; spectral unmixing and operations, computation of composite images; and formation of classified data sets that may include only a subset of available sample images. The classified data set is then submitted to a machine-based classifier, which can be a neural network or another type of classifier. Image pixels may be classified multiple times, and a final classification is performed based o...

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Abstract

Methods are disclosed for classifying different parts of a sample into respective classes based on an image stack that includes one or more images.

Description

technical field [0001] The present invention relates to sorting tissue samples. Background technique [0002] Chromogenic staining techniques have been developed empirically to create visual contrast between various components within a tissue sample. Staining techniques and protocols enable the generation of mixtures of dyes in different tissue components, and using microscopes and other imaging equipment, human observers have learned to distinguish these staining patterns that are unique to specific components. Modern scaled staining methods that can be specific to a certain portion of a chemical molecule and / or to an arrangement of molecular structure can produce stained tissue in which two or more chromogenic or fluorescent stains overlap significantly in space . In fact, either because the multiple colorations are in fact confined to common structures in the sample, or because, due to the preparation method, a structure containing one coloration overlaps a second struc...

Claims

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Application Information

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IPC IPC(8): G06K9/00
CPCG06K9/628G06K9/00127G06K9/6247G06V20/69G06V10/7715G06F18/21G06F18/2135G06F18/2431G06F18/2433
Inventor 理查德·利文森克利福德·C·霍伊特柯克·W·戈西奇
Owner CAMBRIDGE RES & INSTR
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