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A device, system and method for determining the effect of photodynamic or photothermal tumor therapy

A photodynamic and radiant heat technology, applied in phototherapy, radiation therapy, treatment, etc., can solve the problem of not providing tissue therapy effectiveness

Inactive Publication Date: 2008-05-07
SPECTRACURE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These systems do not provide tissue therapy or an evaluation of the effectiveness of the therapy from feedback of the flow signals obtained

Method used

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  • A device, system and method for determining the effect of photodynamic or photothermal tumor therapy
  • A device, system and method for determining the effect of photodynamic or photothermal tumor therapy
  • A device, system and method for determining the effect of photodynamic or photothermal tumor therapy

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Embodiment Construction

[0035] The inventors have surprisingly found that during photodynamic or radiant heat therapy, blood flow through tissue is altered. This can be used to track the progress of the treatment by providing a measure relating to the effectiveness of the treatment.

[0036] In radiant heat therapy, coagulation of blood within tissues occurs when certain thermal interactions occur. This coagulation results in interruption of blood flow and may serve as an indication that treatment may be discontinued.

[0037] Similarly, in photodynamic therapy, blood flow also changes, and this yields information about the progress of the treatment. When blood flows in tissue, including tumor tissue, it transports oxygen to the tissue, and blood flow is a measure of the amount of oxygen transported into the tissue. As will be explained in more detail below, oxygen is necessary in tissues for certain sensitizers to be able to eradicate tissue cells by luminescence, causing tissue necrosis. Sensiti...

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Abstract

A device and method for determining the effect of therapy in a tumour tissue of a human or a mammal under interstitial photodynamic or photothermal therapy by analyzing a liquid flow in a tissue of a human or a mammal. A first fibre is interstitially inserted in a first position of said tissue and connected to a light source, and a second fibre is interstitially inserted in a second position of said tissue for receiving light emitted from the first fibre. A detector is arranged for receiving the light from said second fibre for producing an output signal. An analysator receives the output signal from the detector and determines if there is a frequency component in the frequency area below about 1 MHz in the output signal, which is indicative of blood cell movement in the tissue. If the frequency component is below a threshold value, it is determined that there is no blood flow. In photothermal therapy, no blood flow is interpreted as the fact that the blood has coagulated and the therapy may be finalized. In photodynamic tumour therapy, changes in blood flow may be used to evaluate the treatment progression.

Description

technical field [0001] The present invention relates to devices, systems and methods for determining the efficacy of photodynamic or radiant thermal tumor therapy by interstitial analysis of blood flowing in tissue exposed to the therapy. Background technique [0002] For example in WO 03 / 041575 of the same applicant as the present application, systems and methods for photodynamic tumor therapy and / or radiant thermal tumor therapy using an interactive interstitium for therapy and diagnosis are disclosed. The system includes a plurality of optical fibers inserted into selected locations in tissue to be treated and / or diagnosed, such as cancerous tissue. [0003] For diagnostics, a laser source may be connected to one of the fibers operating as a transmission fiber, and the other fiber operating as a receiver, for passing light through tissue to the other fibers, and then to the detector. Each fiber is used in succession as a transmitter, while the remaining fibers act as rec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/026A61N5/06
CPCA61N2005/063A61B2017/00057A61N5/062A61B5/0261A61N5/0601
Inventor 苏内·斯万贝里卡特里纳·斯万贝里
Owner SPECTRACURE
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