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Application of meletin-7-0-glycoside in mass control of cudrania tricuspidata or preparations thereof

A technology of glucoside, detection method, applied in the field of known compounds

Active Publication Date: 2012-02-08
SHANGHAI LEIYUNSHANG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present inventor obtained quercetin-7-O-glucoside in the separation of the effective components of eucalyptus. According to the comparative analysis of the above-mentioned documents, the plant contains kaempferol-7-O-glucoside and quercetin-glucoside in addition to eucalyptus. Except for the two components of 7-O-glucoside, there have been no reports of other plant species containing the above two components at the same time so far. The inventor believes that if the above two components can be detected simultaneously in the quality control of Zhemu and its preparations, not only can the quality be significantly improved. The specificity of the control items, and the expansion of the number of active ingredients, is conducive to further improving the quality control system of Zhemu and its preparations

Method used

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  • Application of meletin-7-0-glycoside in mass control of cudrania tricuspidata or preparations thereof
  • Application of meletin-7-0-glycoside in mass control of cudrania tricuspidata or preparations thereof
  • Application of meletin-7-0-glycoside in mass control of cudrania tricuspidata or preparations thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] The preparation of embodiment 1 Zhemu dry extract powder

[0080] 100kg Zhe wood small pieces, add 7 times of water, extract for 4 hours, release the liquid medicine, carry out the second extraction, add 5 times of water, extract for 3 hours, combine the extracts, concentrate under reduced pressure to a relative density of 1.07 (80°C), and spray dry , get dry extract powder 5kg.

Embodiment 2

[0081] The dry extract powder preparation of embodiment 2 Zhe wood part extract

[0082] 100kg of Zhe wood small pieces, add 500kg of 60% ethanol, extract for 3 hours, release the medicinal solution, carry out the second extraction, add 400kg of 60% ethanol, extract for 2 hours, combine the extracts, concentrate under reduced pressure until the medicinal solution has no alcohol smell, Pass through a column filled with neutral macroporous resin, then use pure water, 20%, 40%, 60%, 80% ethanol to collect 60-80% ethanol eluate and concentrate and dry to obtain 1.5kg of dry extract powder from the site .

Embodiment 3

[0083] The preparation of embodiment 3 Zhemu granules

[0084] The extract powder prepared in Example 1 was mixed with lactose in a ratio of 2:1, and granulated to obtain yellow-brown granules.

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Abstract

The invention discloses an application of quercetin-7-O-Beta-D-glycoside in quality control of cudrania tricuspidata or the formulation of cudrania tricuspidata and a new quality control method for cudrania tricuspidata or cudrania tricuspidata formulation, relating to a new usage of quercetin-7-O-Beta-D-glycoside, which comprises testing the content of quercetin-7-O-Beta-D-glycoside. The invention provides a whole new index of quercetin-7-O-glycoside for quality control of cudrania tricuspidata or the formulation of cudrania tricuspidata, and has the advantages of remedying the drawback of single index for quality control of cudrania tricuspidata or the formulation very well and improving the quality control system of cudrania tricuspidata formulation.

Description

technical field [0001] The invention relates to a new application of a known compound, in particular to the application of quercetin-7-O-glucoside in the quality control of eucalyptus or its preparations. Background technique [0002] Zhemu is a deciduous shrub or small tree of the genus Cudrania tricuspidata (Carr.) Bun in the Moraceae family. Its function is to clear away heat and cool blood, and it is used for digestive tract tumors in modern folk. The main chemical components are flavonoids, xanthones, lignans, coumarins and polysaccharides. From the 1970s to the 1990s, domestic and foreign scholars (China, Japan and South Korea) conducted research on the anti-cancer effects of Zhemu, and basically confirmed that Flavonoids are anti-cancer and anti-cancer effective components of Zhemu. Polysaccharides participate in immune regulation and have a synergistic effect on anti-cancer. [0003] In China, the development of medicines related to Zhemu began in the 1960s. The su...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/90G01N21/33A61K36/60A61P35/00
Inventor 张国明谢家骏华菊根徐晓英袁华梁
Owner SHANGHAI LEIYUNSHANG PHARMA
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